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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography
|
|---|---|
| Published in |
Nature Communications, July 2015
|
| DOI | 10.1038/ncomms8495 |
| Pubmed ID | |
| Authors |
Agnese Irkle, Alex T. Vesey, David Y. Lewis, Jeremy N. Skepper, Joseph L. E. Bird, Marc R. Dweck, Francis R. Joshi, Ferdia A. Gallagher, Elizabeth A. Warburton, Martin R. Bennett, Kevin M. Brindle, David E. Newby, James H. Rudd, Anthony P. Davenport |
| Abstract |
Vascular calcification is a complex biological process that is a hallmark of atherosclerosis. While macrocalcification confers plaque stability, microcalcification is a key feature of high-risk atheroma and is associated with increased morbidity and mortality. Positron emission tomography and X-ray computed tomography (PET/CT) imaging of atherosclerosis using (18)F-sodium fluoride ((18)F-NaF) has the potential to identify pathologically high-risk nascent microcalcification. However, the precise molecular mechanism of (18)F-NaF vascular uptake is still unknown. Here we use electron microscopy, autoradiography, histology and preclinical and clinical PET/CT to analyse (18)F-NaF binding. We show that (18)F-NaF adsorbs to calcified deposits within plaque with high affinity and is selective and specific. (18)F-NaF PET/CT imaging can distinguish between areas of macro- and microcalcification. This is the only currently available clinical imaging platform that can non-invasively detect microcalcification in active unstable atherosclerosis. The use of (18)F-NaF may foster new approaches to developing treatments for vascular calcification. |
X Demographics
The data shown below were collected from the profiles of 41 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | 34% |
| France | 3 | 7% |
| United Kingdom | 3 | 7% |
| Venezuela, Bolivarian Republic of | 2 | 5% |
| India | 2 | 5% |
| Australia | 1 | 2% |
| Egypt | 1 | 2% |
| Belgium | 1 | 2% |
| Mexico | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 12 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 25 | 61% |
| Scientists | 9 | 22% |
| Practitioners (doctors, other healthcare professionals) | 6 | 15% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 218 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | <1% |
| United States | 1 | <1% |
| Netherlands | 1 | <1% |
| Pakistan | 1 | <1% |
| Unknown | 213 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 24% |
| Researcher | 34 | 16% |
| Student > Master | 21 | 10% |
| Student > Bachelor | 18 | 8% |
| Other | 17 | 8% |
| Other | 37 | 17% |
| Unknown | 38 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 85 | 39% |
| Biochemistry, Genetics and Molecular Biology | 16 | 7% |
| Engineering | 15 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 6% |
| Agricultural and Biological Sciences | 13 | 6% |
| Other | 25 | 11% |
| Unknown | 50 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 53. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2016.
All research outputs
#771,637
of 24,787,209 outputs
Outputs from Nature Communications
#13,006
of 53,926 outputs
Outputs of similar age
#9,068
of 267,602 outputs
Outputs of similar age from Nature Communications
#135
of 788 outputs
Altmetric has tracked 24,787,209 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 53,926 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.0. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,602 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 788 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.