Title |
2018 consensus statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the diagnosis and treatment of cancer of unknown primary
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Published in |
Clinical and Translational Oncology, May 2018
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DOI | 10.1007/s12094-018-1899-z |
Pubmed ID | |
Authors |
F. Losa, L. Iglesias, M. Pané, J. Sanz, B. Nieto, V. Fusté, L. de la Cruz-Merino, Á. Concha, C. Balañá, X. Matías-Guiu |
Abstract |
Cancer of unknown primary (CUP) is defined as a heterogeneous group of tumours that present with metastasis, and in which attempts to identify the original site have failed. They differ from other primary tumours in their biological features and how they spread, which means that they can be considered a separate entity. There are several hypotheses regarding their origin, but the most plausible explanation for their aggressiveness and chemoresistance seems to involve chromosomal instability. Depending on the type of study done, CUP can account for 2-9% of all cancer patients, mostly 60-75 years old. This article reviews the main clinical, pathological, and molecular studies conducted to analyse and determine the origin of CUP. The main strategies for patient management and treatment, by both clinicians and pathologists, are also addressed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 5 | 71% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 14% |
Other | 6 | 10% |
Student > Postgraduate | 5 | 9% |
Student > Bachelor | 4 | 7% |
Lecturer > Senior Lecturer | 3 | 5% |
Other | 9 | 16% |
Unknown | 23 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 41% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Agricultural and Biological Sciences | 2 | 3% |
Nursing and Health Professions | 1 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 1 | 2% |
Unknown | 26 | 45% |