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Attention Score in Context
| Title |
Effect of copper intake on CSF parameters in patients with mild Alzheimer’s disease: a pilot phase 2 clinical trial
|
|---|---|
| Published in |
Journal of Neural Transmission, October 2008
|
| DOI | 10.1007/s00702-008-0136-2 |
| Pubmed ID | |
| Authors |
Holger Kessler, Frank-Gerald Pajonk, Daniela Bach, Thomas Schneider-Axmann, Peter Falkai, Wolfgang Herrmann, Gerd Multhaup, Jens Wiltfang, Stephanie Schäfer, Oliver Wirths, Thomas A. Bayer |
| Abstract |
A plethora of reports suggest that copper (Cu) homeostasis is disturbed in Alzheimer's disease (AD). In the present report we evaluated the efficacy of oral Cu supplementation on CSF biomarkers for AD. In a prospective, randomized, double-blind, placebo-controlled phase 2 clinical trial (12 months long) patients with mild AD received either Cu-(II)-orotate-dihydrate (verum group; 8 mg Cu daily) or placebo (placebo group). The primary outcome measures in CSF were Abeta42, Tau and Phospho-Tau. The clinical trial demonstrates that long-term oral intake of 8 mg Cu can be excluded as a risk factor for AD based on CSF biomarker analysis. Cu intake had no effect on the progression of Tau and Phospho-Tau levels in CSF. While Abeta42 levels declined by 30% in the placebo group (P = 0.001), they decreased only by 10% (P = 0.04) in the verum group. Since decreased CSF Abeta42 is a diagnostic marker for AD, this observation may indicate that Cu treatment had a positive effect on a relevant AD biomarker. Using mini-mental state examination (MMSE) and Alzheimer disease assessment scale-cognitive subscale (ADAS-cog) we have previously demonstrated that there are no Cu treatment effects on cognitive performance, however. Finally, CSF Abeta42 levels declined significantly in both groups within 12 months supporting the notion that CSF Abeta42 may be valid not only for diagnostic but also for prognostic purposes in AD. |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Netherlands | 1 | 1% |
| Unknown | 92 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 15% |
| Student > Master | 14 | 15% |
| Student > Bachelor | 9 | 10% |
| Other | 6 | 6% |
| Student > Ph. D. Student | 6 | 6% |
| Other | 18 | 19% |
| Unknown | 27 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 24% |
| Agricultural and Biological Sciences | 7 | 7% |
| Neuroscience | 6 | 6% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Psychology | 4 | 4% |
| Other | 15 | 16% |
| Unknown | 35 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2018.
All research outputs
#7,467,331
of 22,828,180 outputs
Outputs from Journal of Neural Transmission
#631
of 1,766 outputs
Outputs of similar age
#32,360
of 91,820 outputs
Outputs of similar age from Journal of Neural Transmission
#4
of 9 outputs
Altmetric has tracked 22,828,180 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,766 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 91,820 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.