Interesting.. Potential Mechanisms for Cancer Resistance in Elephants vs Humans https://t.co/C6uUk16r0h
RT @MamMa_mimumemo: ゾウ🐘が、がんになりにくいのは、「TP53を20コピー持ってるから」って、まじか…😱 https://t.co/nCxCVzsh30
ゾウ🐘が、がんになりにくいのは、「TP53を20コピー持ってるから」って、まじか…😱 https://t.co/nCxCVzsh30
RT @tilbots: Elephants resist cancer because of a gene called P53 that can either order repair of a damaged cell, or order to kill it. Most…
Elephants resist cancer because of a gene called P53 that can either order repair of a damaged cell, or order to kill it. Most of the time P53 chooses the latter. The LIF6 gene carries out the orders to eliminate the cancerous cells. https://t.co/yp7mQHyX3
Most fascinating was observation of enhanced cancer suppression in large long-lived animals. @jdschiffman (with @cmaley & @ace_arizona) found that elephants have multiple additional TP53 copies https://t.co/obubBF8zTx & thinks elephant TP53 has par
RT @HenryJOncology: @Atul_Gawande Standing on shoulders from 2015 @JAMANetwork https://t.co/bjkyF5sodu https://t.co/33fwRTgFl9
@Atul_Gawande Standing on shoulders from 2015 @JAMANetwork https://t.co/bjkyF5sodu https://t.co/33fwRTgFl9
I was surprised to see this 2015 paper on the topic in JAMA: https://t.co/GuqZy83yiW
Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans 🐘 https://t.co/g87cKOa9XT Elephants had lower-than-expected rate of cancer, potentially related to multiple copies of TP53 & ⬆️apoptotic
2015. Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans ... https://t.co/K2BqKcgJOT
@Dr_Mimz + In elephant, p53 is more sensitive to DNA damage (inoizing radiation) than human. https://t.co/YF8h3ggfDc https://t.co/ATSJumjQY4
RT @nickmmark: Other answers: Elephants & bowhead whales are both exceptionally long-lived and highly cancer resistant. The elephant (lif…
RT @nickmmark: Other answers: Elephants & bowhead whales are both exceptionally long-lived and highly cancer resistant. The elephant (lif…
@ToriHerridge @ChrisWidga @MostlyMammoths @KabwePRQ @tim_fedak @AltonDooley @alinemghilardi @amjukar @carrieeaton @cherbel18 @DimilaMothe @Dr_Mastodonna Wow! Very cool, would love to know if it is osteosarcoma! While rare elephants do get cancers… https:
@Spoof_Junkey Major part of ancient Knowledge has been destroyed by invaders. To understand things we need to explore them again. And modern science is helping. https://t.co/4KSHx5y4zL
@webvein @KingRexy328 “Despite their large body size and long life span, elephants remain cancer resistant, with an estimated cancer mortality of 4.81% compared with humans, who have 11% to 25%cancer mortality.” Source (https://t.co/MSmgwH8nnT)
🤯 marededeutotjunttotplegat!!!!! 🐘 TP53 & low rates of cancer👇
RT @CaloriesProper: Elephants are fucking awesome. They have like, 20 copies of the tumor suppressor p53 (compared to humans, who have 2) h…
African Elephants have a 2-5 times lower risk of developing cancer than humans. This is because they have 20 copies of the tumour suppressor gene TP53 whereas humans have only one. #ScienceFactOfTheDay https://t.co/gm0Y950Nwj https://t.co/gR7wLpVmz4
RT @CaloriesProper: Elephants are fucking awesome. They have like, 20 copies of the tumor suppressor p53 (compared to humans, who have 2) h…
RT @CaloriesProper: Elephants are fucking awesome. They have like, 20 copies of the tumor suppressor p53 (compared to humans, who have 2) h…
Elephants are fucking awesome. They have like, 20 copies of the tumor suppressor p53 (compared to humans, who have 2) https://t.co/H488ctQqyu Estimated cancer mortality in elephants: ~5%; humans: ~18% They're also pretty smart https://t.co/t0eaGlJwb1
RT @nickmmark: Other answers: Elephants & bowhead whales are both exceptionally long-lived and highly cancer resistant. The elephant (lif…
RT @nickmmark: Other answers: Elephants & bowhead whales are both exceptionally long-lived and highly cancer resistant. The elephant (lif…
Other answers: Elephants & bowhead whales are both exceptionally long-lived and highly cancer resistant. The elephant (lifespan up to 70 years) has 19 additional copies of the p53 tumor suppressor, which makes it highly cancer resistant. https://t.co
RT @erlesen: Wild animals have many p53 variations that contribute to environmental adaptation and cancer resistance https://t.co/BH6jz0rM4…
@HSalmonowicz @R_Amadio Cancer is a major factor in limiting human life span ... so I also vote for research on elephants - and Peto’s paradox. https://t.co/qul17XlsMr
@JBorniger Elderly have more cell divisions, and have higher cancer risk. More cancers in frequently dividing cells than not. Post-mitotic cells can be kicked out of G0 by mutation. Elephants which have way more cells and divisions than us have 40 copies (
RT @JAMA_current: On #WorldElephantDay (What?) reread our analysis of cancer genetics in elephants Larger size and cell mass should mean m…
We began this project after publication of the 2015 JAMA paper describing the discovery of extra copies of TP53 in elephants. Cancer data was collected from a pathology handbook. https://t.co/IiQJcPO93j
Still my favorite scientific paper in terms of studying a hypothesis and determining a novel explanation. Elephants rarely get cancer —> turns out they have extra copies of p53. https://t.co/QdbRKXLzMc
TP53 is an important tumor suppressor and the African elephant genome has ~19 retrogene copies - this is related to an enhanced apoptotic response to DNA damage https://t.co/bBg8JWfktb https://t.co/fhqN89lenV == cancer resistance in elephants... but
Asian elephants are more likely to be infected with tuberculosis https://t.co/SYuw2wA4vf what gives? and what about cancer? we know elephants get less cancer than a similarly sized human would https://t.co/fhqN89lenV
RT @DevoEvoMed: So we have some theory that predicts a positive correlation between body size, lifespan and cancer risk and evidence of suc…
We and others have used candidate gene approaches to explore whether elephant genomes encode extra copies of tumor suppressors ...Seems like they do https://t.co/eWnczQG4Vz https://t.co/FeUh8FyroN https://t.co/QlXMwpB7nO https://t.co/DihQsrmrAd
So we have some theory that predicts a positive correlation between body size, lifespan and cancer risk and evidence of such a correlation within species...But, between species there is no correlation between either body size or lifespan and cancer risk!
RT @JAMA_current: On #WorldElephantDay (What?) reread our analysis of cancer genetics in elephants Larger size and cell mass should mean m…
RT @JAMA_current: Elephants have at least 20 copies of tumor suppressor gene TP53 => more apoptosis => presumed mechanism for less cancer…
RT @JAMA_current: On #WorldElephantDay (What?) reread our analysis of cancer genetics in elephants Larger size and cell mass should mean m…
RT @JAMA_current: On #WorldElephantDay (What?) reread our analysis of cancer genetics in elephants Larger size and cell mass should mean m…
RT @JAMA_current: Elephants have at least 20 copies of tumor suppressor gene TP53 => more apoptosis => presumed mechanism for less cancer…
RT @JAMA_current: Elephants have at least 20 copies of tumor suppressor gene TP53 => more apoptosis => presumed mechanism for less cancer…
RT @JAMA_current: On #WorldElephantDay (What?) reread our analysis of cancer genetics in elephants Larger size and cell mass should mean m…
RT @JAMA_current: Elephants have at least 20 copies of tumor suppressor gene TP53 => more apoptosis => presumed mechanism for less cancer…
RT @JAMA_current: On #WorldElephantDay (What?) reread our analysis of cancer genetics in elephants Larger size and cell mass should mean m…
Elephants have at least 20 copies of tumor suppressor gene TP53 => more apoptosis => presumed mechanism for less cancer https://t.co/8zMDVoef1R
On #WorldElephantDay (What?) reread our analysis of cancer genetics in elephants Larger size and cell mass should mean more tumors, but the species has less in proportion to size, Why? https://t.co/8zMDVoef1R
RT @Science_Open: It's #WorldElephantDay: 'Potential Mechanisms for #Cancer Resistance in Elephants and Comparative Cellular Response to DN…
It's #WorldElephantDay: 'Potential Mechanisms for #Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans.' a @JAMANetwork article found on #ScienceOpen: https://t.co/pwwdwlxbxg
RT @callmejoe9: What has been found in elephants is that they have duplicate copies of the TP53 gene. This gene regulates apoptosis, which…
What has been found in elephants is that they have duplicate copies of the TP53 gene. This gene regulates apoptosis, which is the process causing damaged cells to kill themselves before they can become tumors. https://t.co/HVD0D3tXCv
RT @erlesen: Wild animals have many p53 variations that contribute to environmental adaptation and cancer resistance https://t.co/BH6jz0rM4…
RT @NatureEcoEvo: Lisa Abegglen on different responses to doxorubicin in humans and elephants, and wider context of species that don't get…
@hillelogram Interestingly, elephant cells also exhibit apoptosis when damaged - more aggressively than mice. https://t.co/iIRT64o3um Metabolism, size, and cell survival seem intrinsically and complexly linked. https://t.co/yTrGFtyDWu
Potential Mechanisms for Cancer Resistance in Elephants vs Humans https://t.co/7844zUE6Id
RT @oncologiavet: Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans. https…
Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans. https://t.co/YbXMzMsIc4
RT @erlesen: Wild animals have many p53 variations that contribute to environmental adaptation and cancer resistance https://t.co/BH6jz0rM4…
RT @erlesen: Wild animals have many p53 variations that contribute to environmental adaptation and cancer resistance https://t.co/BH6jz0rM4…
Wild animals have many p53 variations that contribute to environmental adaptation and cancer resistance https://t.co/BH6jz0rM4d p53 plays a main role in cancer suppression and response to DNA damage through apoptosis https://t.co/0n4AZiUDCn Tumorsuppressor
RT @NatureEcoEvo: Lisa Abegglen on different responses to doxorubicin in humans and elephants, and wider context of species that don't get…
RT @NatureEcoEvo: Lisa Abegglen on different responses to doxorubicin in humans and elephants, and wider context of species that don't get…
RT @NatureEcoEvo: Lisa Abegglen on different responses to doxorubicin in humans and elephants, and wider context of species that don't get…
RT @NatureEcoEvo: Lisa Abegglen on different responses to doxorubicin in humans and elephants, and wider context of species that don't get…
Lisa Abegglen on different responses to doxorubicin in humans and elephants, and wider context of species that don't get as much cancer as they should https://t.co/BEl02fnFNU https://t.co/Ffqz5Vq8c6 #CancerEvoEco19
RT @YYOI: ゾウのP53、原著これか。DNAにダメージ与えても、ちゃんとがん化しなかったぜ!的なところまでは調べてるみたいだな; Potential Mechanisms for Cancer Resistance in Elephants v http://t.co/…
RT @SmootSienna: Elephants are cancer resistant. They have 40 copies of tumor suppressor genes that resist cancer. Humans have 2. 🤔 CRISPR?…
Elephants are cancer resistant. They have 40 copies of tumor suppressor genes that resist cancer. Humans have 2. 🤔 CRISPR? Potential Mechanisms for Cancer Resistance in Elephants&Comparative Cell Response to DNA Damage. https://t.co/C14mIqiiJS
Source: https://t.co/vsBALbUP2V (h/t >> https://t.co/3yxI4hGuEY) https://t.co/7WW1wqdODe
Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. https://t.co/yFa3iri2oI
RT @oncologiavet: Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. https…
RT @AdhesionLab: Fascinating!! Despite their large body size and long life span, elephants remain cancer resistant, with an estimated cance…
Wow. Now that's interesting
RT @AdhesionLab: Fascinating!! Despite their large body size and long life span, elephants remain cancer resistant, with an estimated cance…
RT @AdhesionLab: Fascinating!! Despite their large body size and long life span, elephants remain cancer resistant, with an estimated cance…
RT @doctoralvarez: Los elefantes tienen grandes dimensiones y una expectativa de vida prolongada, a pesar de ello tienen una de las tasas d…
RT @AdhesionLab: Fascinating!! Despite their large body size and long life span, elephants remain cancer resistant, with an estimated cance…
@SafiaDanovi @oh_henry See the JAMA 2015 paper for an estimate https://t.co/267R8yCKn2
RT @AdhesionLab: Fascinating!! Despite their large body size and long life span, elephants remain cancer resistant, with an estimated cance…
RT @abribriesco43: #cancerresearch on genetic basis for cancer resistance humans vs elephants. Elephants have increased capacity for bot…
Cancer resistance in elephants 🐘💪 https://t.co/fYcT1D7fiE
RT @AdhesionLab: Fascinating!! Despite their large body size and long life span, elephants remain cancer resistant, with an estimated cance…
RT @abribriesco43: #cancerresearch on genetic basis for cancer resistance humans vs elephants. Elephants have increased capacity for bot…
#cancerresearch on genetic basis for cancer resistance humans vs elephants. Elephants have increased capacity for both DNA repair (^^TP53) and p53-driven apoptosis. https://t.co/IKf2tEO1zB @jbmitchem @UsmanAhmadMD @DanRaymondMD @n8pennell @scientistatlr
RT @AdhesionLab: Fascinating!! Despite their large body size and long life span, elephants remain cancer resistant, with an estimated cance…
Ci potrebbe aiutare a capire come trattare le malattie dell’uomo. Davvero affascinante,
RT @doctoralvarez: Los elefantes tienen grandes dimensiones y una expectativa de vida prolongada, a pesar de ello tienen una de las tasas d…
RT @oncologiavet: Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. https…
Los elefantes tienen grandes dimensiones y una expectativa de vida prolongada, a pesar de ello tienen una de las tasas de mortalidad por cáncer más bajas en comparación con los humanos.
Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. https://t.co/bYpxabDqpX
RT @AdhesionLab: Fascinating!! Despite their large body size and long life span, elephants remain cancer resistant, with an estimated cance…
RT @AdhesionLab: Fascinating!! Despite their large body size and long life span, elephants remain cancer resistant, with an estimated cance…
RT @AdhesionLab: Fascinating!! Despite their large body size and long life span, elephants remain cancer resistant, with an estimated cance…
Another reason to like elephants....@yashar