Title |
Use of tramadol in early pregnancy and congenital malformation risk
|
---|---|
Published in |
Reproductive Toxicology, October 2015
|
DOI | 10.1016/j.reprotox.2015.10.007 |
Pubmed ID | |
Authors |
Bengt Källén, Margareta Reis |
Abstract |
Only few studies exist regarding the risk of a teratogenic effect of tramadol when used in early pregnancy. Using the Swedish Medical Birth Register, women (deliveries in 1997-2013) who had reported the use of tramadol in early pregnancy were identified. Maternal characteristics and concomitant drug use were analyzed. Among 1 682 846 women (1 797 678 infants), 1751 (1776 infants) had used tramadol, 96 of the infants had a congenital malformation and 70 of them were relatively severe. The adjusted odds ratio for a relatively severe malformation was 1.33 (95% CI 1.05-1.70). The odds ratios for cardiovascular defects (1.56, 95% CI 1.04-2.29) and for pes equinovarus (3.63, 95% CI 1.61-6.89) were significantly increased. The study suggests a teratogenic effect of tramadol but the risk increase is moderate. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 72 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 12 | 17% |
Student > Master | 7 | 10% |
Other | 7 | 10% |
Researcher | 4 | 6% |
Student > Ph. D. Student | 4 | 6% |
Other | 13 | 18% |
Unknown | 25 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 29% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 13% |
Nursing and Health Professions | 4 | 6% |
Unspecified | 3 | 4% |
Computer Science | 2 | 3% |
Other | 8 | 11% |
Unknown | 25 | 35% |