@Boiler725 @kristal1122 @dianaberrent @DickNYC1 @mileswgriffis @WesElyMD @JReinerMD @PeterHotez @EricTopol @DrEricDing That’s barely a statistically significant difference, and it is ode-Covid: https://t.co/QRxyPLM9ga
Next, ASPREE - ASA 100mg vs placebo did not reduce the risk of major CVD events, but increased the risk of bleeding in healthy, older adults. 12/20 https://t.co/FnOsGvqqiF https://t.co/VxgMdlTe5g
RT @venkmurthy: ASPREE Trial results: https://t.co/Vsw2Pk5cn4
ASPREE Trial results: https://t.co/Vsw2Pk5cn4
@InvestorSwan You would think so, but it doesn't always turn out as such: https://t.co/Vsw2PkmNLE
RT @haroldpollack: Nice example of great trial with null result. https://t.co/7gY5lxtrDC
Nice example of great trial with null result.
@haroldpollack This RCT surprised me. I've regarded low dose aspirin as more likely to help than harm, like I took it while trying to conceive my two kids in late 30s and early 40s based on inconclusive but suggestive evidence. https://t.co/q2SR0p7nx8
@Dromercay @AhmetBeyefendi @Martha_Vickers Endikasyon olmadan rutin ASA kullanımı mortalite ve morbiditeyi artırıyor. Net etki negatif, fayda zarar hesabında zarar ağır basıyor. Örnek çalışmalardan biri: https://t.co/L807AsIQRn
RT @raphaels7: « Higher all-cause mortality was observed among apparently healthy older adults who received daily aspirin than among those…
RT @raphaels7: « Higher all-cause mortality was observed among apparently healthy older adults who received daily aspirin than among those…
« Higher all-cause mortality was observed among apparently healthy older adults who received daily aspirin than among those who received placebo & was attributed primarily to cancer-related death » https://t.co/TkkLF5EiHX N = 19k placebo controlled RC
@LeonardChoong @alexandrosM And this was after decades of advice that otherwise healthy people should take aspirin (trial is here: https://t.co/a1cSeHeaaU)
@Psy_Checko @DocEliMarquez Que se continúen haciendo estudios no significa que no debamos vacunarnos. Aun se sigue estudiando la aspirina que tiene mas de 100 años. La ciencia no se detiene https://t.co/YEq61fvXd9
@fragoua Safe is a layman’s term. The risk benefit considerations from control studies is far better indications. How safe should vaccines be? As safe as aspirin? What is certain is unvaccinated have higher likelyhood of death from Covid. Freedom to choos
RT @agingdoc1: Aspirin and cancer survival: a systematic review and meta-analyses of 118 observational studies of aspirin and 18 cancers ht…
"There is a considerable body of evidence suggestive of about a 20% reduction in mortality in patients with cancer who take aspirin, and the benefit appears not to be restricted to one or a few cancers."
Aspirin and cancer survival: a systematic review and meta-analyses of 118 observational studies of aspirin and 18 cancers https://t.co/Fs5QDGnb0K Supports ASA as chemoprotective while other data suggests caution as primary prevention (https://t.co/Pug0nfD
@negromanten1 Aspirina causa 15.000 morti all'anno. Ci sono molti studi. Adesso non trovo quello giusto https://t.co/2ZjkO1Qnjp
@naughtynell101 @9MarksOutOf10 @JustABlackMan39 @PolitiFact Did you know aspirin is more dangerous than this vaccine? Here are 2 links to get you started: https://t.co/JQF8EMMkRs https://t.co/0dVIfwzztt
@PaulBateman3 @Progressive_Con @commonsense058 We got it wrong about Aspirin for years https://t.co/0bzuZsEQbI
RT @Drug_Evidence: 6/7 Ex. 5: ASPREE trial of 19,000 pts >70yrs, without CVD found: 👉ASA showed NO difference in terms of dementia and pe…
Effect of aspirin on all-cause mortality https://t.co/7HS7D2jbUb https://t.co/VIFifS1lAt
@TheDennisMenice @lassitlaitala @AnnaKorhonen3 @1000histoires Itse asiassa uudemmat tutkimukset osoittavat, että aspiriini TERVEILLÄ voi olla haitallista, eikä sitä siten suositellakaan. Tilanne muuttuu, kun on vakavia verenkiertoelimien riskitekijöitä tai
6/7 Ex. 5: ASPREE trial of 19,000 pts >70yrs, without CVD found: 👉ASA showed NO difference in terms of dementia and persistent disability, BUT 👉1.6 excess deaths per 1,000 person years compared to placebo: https://t.co/TEGa6ITZDS 😯 #MedEd #ptsafety h
I love when I get to teach PGY3 residents who are pretty much ready to be attendings something - today, it is when a nonagenarian comes in from adverse bleeding effects of NSAIDs, they do NOT need to be on aspirin for "primary prevention" https://t.co/7T3b
Effect of Aspirin on All-Cause Mortality in the Healthy Elderly | NEJM https://t.co/kR3GUUfqpS
There’s good evidence for secondary prevention in CVD. Not so much for primary prevention. https://t.co/xvZbBD2VQV @NEJM https://t.co/SCmXh5E3d8
@ZikaMika6 @cladelucia @SciReports @LuigiFontana22 Dose is relevant & bleeding is problematic. Molecular mimickers without off target effects would be optimal for ⬆️study. There remains controversy even for lower dose, with caution for both over&
@davidasinclair There is one study with increased all-cause mortality in elderlies due to higher cancer-risk https://t.co/nbtMrjcVwS
@Sir_Liptonn @ninoguzzo @DogDuffy @Bowenchris We've been wrong about aspirin for years. It causes net harm to many people. Only know now because it's been properly tested https://t.co/0bzuZsneN8
RT @m0370: アスピリンは心疾患死亡を下げるけど癌死亡は増えてるんじゃね?って話はアスピリンRCTのASPREE試験の時からうっすら出ていた。まあ、なぜこういう結果が出たのかはよくわからん。(普通は抗炎症作用があれば腫瘍は減ることはあっても増えることはなさそうだが。。。…
アスピリンは心疾患死亡を下げるけど癌死亡は増えてるんじゃね?って話はアスピリンRCTのASPREE試験の時からうっすら出ていた。まあ、なぜこういう結果が出たのかはよくわからん。(普通は抗炎症作用があれば腫瘍は減ることはあっても増えることはなさそうだが。。。) /NEJM https://t.co/RbjLV9Qbdz
RT @LastCardiology: @VPrasadMDMPH @venkmurthy The best analogy I can think of as to why using unproven vaccines would be a bad idea https:/…
RT @LastCardiology: @VPrasadMDMPH @venkmurthy The best analogy I can think of as to why using unproven vaccines would be a bad idea https:/…
RT @LastCardiology: @VPrasadMDMPH @venkmurthy The best analogy I can think of as to why using unproven vaccines would be a bad idea https:/…
@VPrasadMDMPH @venkmurthy The best analogy I can think of as to why using unproven vaccines would be a bad idea https://t.co/Czpg2pSpd7
RT @NEJM: The ASPREE trials: #Aspirin and Disability-free Survival in Healthy Elderly https://t.co/QUFKIcTuPI Effect of Aspirin on All-Ca…
RT @Luke_629: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly アスピリン服薬群のほうが死亡率が高い。主にがんによるもの。解釈に注意が必要。NEJM https://t.co/8pUTJ…
RT @Luke_629: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly アスピリン服薬群のほうが死亡率が高い。主にがんによるもの。解釈に注意が必要。NEJM https://t.co/8pUTJ…
Effect of Aspirin on All-Cause Mortality in the Healthy Elderly アスピリン服薬群のほうが死亡率が高い。主にがんによるもの。解釈に注意が必要。NEJM https://t.co/8pUTJkJ5xt
RT @jsenior64: Aspirina en prevención primaria. Recapitulando estudios recientes. https://t.co/tLBDfQZuLM
Gracias profe por mantenernos informados .. Al pie de su twitterr diariamente .. un abrazo saludos
Aspirina en prevención primaria. Recapitulando estudios recientes. https://t.co/tLBDfQZuLM
@Freydrik @EricBillyFR @LeCamusC @idg_pharma @nicogans51 @castanul @QtScience @LaurentRandom @delamare41 @Mana22565984 @SankavaraSci @Le___Doc @Fraslin @LehmannDrC @MarcGozlan @raoult_didier Mais vous lisez ce qu'on vous dit ou vous êtes persuadé de déteni
A recent research study conducted at Monash University in Australia have examined the role of taking anti-coagulant medications, particularly aspirin, in healthy elderly individuals. Excess bleeding was found to be associated with aspirin use. #biom4180 h
Si vous avez choisi l'ASPIRINE, vous ne ferez pas moins d'attaque cérébrale ou d'infarctus. Par contre votre risque de mourir augmente de 14% par rapport à ceux qui ont choisi le placebo https://t.co/u7BPfGA5t1
@HTNCanada what are your thoughts re: this article? Should we still have conversations about aspirin in hypertensive pts over 50? https://t.co/IA3xZD7Row
But hard to make sense of the finding that aspirin is associated with INCREASED cancer-related death in elderly patients https://t.co/VbVLC7aefb
@DrEstfan @JesusMBanales I might avoid it in patients above the age of 70 if they are not on it for other reasons. https://t.co/TcBIykMIhk
@lisabodnar @robertwplatt Aspirin is a recently controversial one. Long term low-dose aspirin being beneficial to heart disease risk, but possibly increasing the risk of all-cause cancer mortality. https://t.co/OtzkM6GBKf
@kevinnbass ASPREE reported a higher cumulative incidence of cancer-related death with low dose ASA (hazard ratio, 1.31; 95% CI, 1.10-1.56). https://t.co/5FfZM5DfKV
Great thread
RT @AlishyaBurrell: Dug back in @camilla_wong’s feed for these gems from CGS 2019 in Halifax! For anyone three weeks away from their Geri @…
Dug back in @camilla_wong’s feed for these gems from CGS 2019 in Halifax! For anyone three weeks away from their Geri @Royal_College exam... may come in super handy! live tweeting this quickly isn’t easy - greatly appreciated! @CanGeriSoc @GeriInterestGp
RT @rincondesisifo: (NEJM) Dosis bajas de ácido acetilsalicílico en ancianos sanos ↑mortalidad por cualquier causa vs placebo https://t.co/…
@Turing_Tester_ @RyanMarino Also, unless you have cardiovascular risk factors, prolonged use of aspirin isn’t particularly safe either. Please see the recent #ASPREE trials in the NEJM. https://t.co/0Z4hSCQ3yR
And that’s all until next year, folks! @CanGeriSoc @NGIG1415 #CGSHalifax2019
#1. ASPREE (more than one publication): https://t.co/mVlSnfCBBf and https://t.co/Cu2Lx4Ay4n #CGSHALIFAX2019
@Exifam Reference: Aspree trial. https://t.co/aRy6E05EMi
RT @NEJM: Original Article: Effect of #Aspirin on All-Cause Mortality in the Healthy Elderly (ASPREE) https://t.co/Cn2Ot9f1ka https://t.co/…
Effect of Aspirin on All-Cause Mortality in the Healthy Elderly https://t.co/QNRMgNjBDC #NEJM #HealthNews #HealthHeadlines
@3DiMMUNE "enforced acetylation of #cGAS by aspirin robustly suppresses self-DNA-induced autoimmunity", this might be part of an explanation why low dose aspirin was associated with an increased incidence rate of cancer in people aged 70+ https://t.co/LAwa
Effect of Aspirin on All-Cause Mortality in the Healthy Elderly | NEJM https://t.co/93ySF95RDh #psh_plas2019
Effect of Aspirin on All-Cause Mortality in the Healthy Elderly https://t.co/3FdJOluyZc #NEJM #HealthNews #HealthHeadlines https://t.co/OlY3umh9VO
+ una mayor mortalidad (https://t.co/yhRNB6ttOU).
RT @NathanStall: 1. ASPREE trials via @NEJM: aspirin for primary prevention in older adults. Aspirin had no effect on disability-free survi…
RT @NathanStall: 1. ASPREE trials via @NEJM: aspirin for primary prevention in older adults. Aspirin had no effect on disability-free survi…
RT @NathanStall: 1. ASPREE trials via @NEJM: aspirin for primary prevention in older adults. Aspirin had no effect on disability-free survi…
RT @NathanStall: 1. ASPREE trials via @NEJM: aspirin for primary prevention in older adults. Aspirin had no effect on disability-free survi…
1. ASPREE trials via @NEJM: aspirin for primary prevention in older adults. Aspirin had no effect on disability-free survival (https://t.co/ddjGtx1Oxj) and cardiovascular events (https://t.co/KgJNHnn8nK) while increasing bleeding and all-cause mortality (h
Our Friday paper of the week is chosen by @OlderTrialsProf - Effect of Aspirin on All-Cause Mortality in the Healthy Elderly, McNeil et al (2018) https://t.co/CDQVqUw9YR
RT @stirproftip: As is often the case, long-term use of a drug = bad. "This study on the effectiveness of prescribing aspirin as a preventa…
As is often the case, long-term use of a drug = bad. "This study on the effectiveness of prescribing aspirin as a preventative measure for a variety of ailments in the elderly provides more evidence that this treatment may lead to increased risk of death."
Aspirine gebruik grotere kans op kanker! https://t.co/HIPgcSvwnP
RT @enenbee: RCT of aspirin vs placebo in older individuals without cardiovascular disease (the ASPREE trial) demonstrates ⬆️ all cause mor…
Daily use of #aspirin does not reduce all-cause mortality in healthy older adults; and even led to slight unexpected increases, attributable to more cancer-related deaths. @NEJM https://t.co/OIuXWlWbJv #cancer #academicdetailing
RT @iforumrx: It's aspirin in the elderly week. What are your thoughts? "Effect of Aspirin on All-Cause Mortality in the Healthy Elderly" h…
Daily use of #aspirin does not reduce all-cause mortality in healthy older adults; and even led to slight unexpected increases, attributable to more cancer-related deaths. @NEJM https://t.co/OIuXWlWbJv #cancer #academicdetailing
It's aspirin in the elderly week. What are your thoughts? "Effect of Aspirin on All-Cause Mortality in the Healthy Elderly" https://t.co/a09vxS6BqC
@UsuarezMD @mgalandejuana Hace poco se desaconsejo el ASA para prevención primaria https://t.co/vDcyHOFvkC
In this RCT of 19,114 patients over the age of 70 without CV disease, dementia or disability, aspirin use was associated with a higher all-cause mortality than placebo. This was attributed primarily to cancer-related death. #aspirin #cancer https://t.co/W
RT @RevistaMFSamfyc: Efecto de la aspirina sobre la mortalidad por cualquier causa en la vejez saludable https://t.co/JVnaI11Uxr PMID 30221…
Interesting. This is though in people >70 old, without obvious cardiovascular stuff and for a period of time which may be not enough to prevent cancer, although cancer mortality is in fact higher in aspirin group https://t.co/1VGuWYv9jO
Efecto de la aspirina sobre la mortalidad por cualquier causa en la vejez saludable https://t.co/JVnaI11Uxr PMID 30221595
I thought the ASA debate was settled for now, as there was an increase in all cause mortality in healthy older patients taking ASA mainly due to cancer related deaths. https://t.co/LpLYFYfXTB
@harvardmed Seems to contradict this study: https://t.co/W1q05g6X1C
RT @XBayona: “En mayores sanos de 70 años o más, que tomaban AAS en prevención primaria tubieron mayor mortalidad que aquellos que que sólo…
RT @jvillacastin: Se debe recomendar la toma de aspirina 100 mg a personas sanas, mayores de 65-70 años? En este estudio, a los 5 años los…
@BullyEsq For anyone on either side of this, studies on flu vaccine efficacy are complex w/ many confounding variables. Even the effectiveness of aspirin in elderly was called into question this month when a NEJM study showed that it actually increases mor
RT @NEJM: ASPREE trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly https://t.co/Cn2Ot9f1ka Editorial: Should Aspirin…
お疲れ様です。 今日の勉強会のお題は、NEJMの原著論文より、健康な高齢者における全死因死亡率に対するアスピリンの効果、でした。適応がない場合には、むしろ癌、しかも大腸癌が増えて死亡率が上がるという、衝撃的な結果ですけど、そんなに盛り上がってないのでしょうか? https://t.co/RrqmLr7qhH