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Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

Overview of attention for article published in PLoS Pathogens, March 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
9 news outlets
blogs
1 blog
twitter
75 X users
patent
2 patents
facebook
31 Facebook pages
wikipedia
1 Wikipedia page
googleplus
1 Google+ user
video
1 YouTube creator

Citations

dimensions_citation
209 Dimensions

Readers on

mendeley
278 Mendeley
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Title
Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor
Published in
PLoS Pathogens, March 2016
DOI 10.1371/journal.ppat.1005531
Pubmed ID
Authors

Yunjeong Kim, Hongwei Liu, Anushka C. Galasiti Kankanamalage, Sahani Weerasekara, Duy H. Hua, William C. Groutas, Kyeong-Ok Chang, Niels C. Pedersen

Abstract

Coronaviruses infect animals and humans causing a wide range of diseases. The diversity of coronaviruses in many mammalian species is contributed by relatively high mutation and recombination rates during replication. This dynamic nature of coronaviruses may facilitate cross-species transmission and shifts in tissue or cell tropism in a host, resulting in substantial change in virulence. Feline enteric coronavirus (FECV) causes inapparent or mild enteritis in cats, but a highly fatal disease, called feline infectious peritonitis (FIP), can arise through mutation of FECV to FIP virus (FIPV). The pathogenesis of FIP is intimately associated with immune responses and involves depletion of T cells, features shared by some other coronaviruses like Severe Acute Respiratory Syndrome Coronavirus. The increasing risks of highly virulent coronavirus infections in humans or animals call for effective antiviral drugs, but no such measures are yet available. Previously, we have reported the inhibitors that target 3C-like protease (3CLpro) with broad-spectrum activity against important human and animal coronaviruses. Here, we evaluated the therapeutic efficacy of our 3CLpro inhibitor in laboratory cats with FIP. Experimental FIP is 100% fatal once certain clinical and laboratory signs become apparent. We found that antiviral treatment led to full recovery of cats when treatment was started at a stage of disease that would be otherwise fatal if left untreated. Antiviral treatment was associated with a rapid improvement in fever, ascites, lymphopenia and gross signs of illness and cats returned to normal health within 20 days or less of treatment. Significant reduction in viral titers was also observed in cats. These results indicate that continuous virus replication is required for progression of immune-mediated inflammatory disease of FIP. These findings may provide important insights into devising therapeutic strategies and selection of antiviral compounds for further development for important coronaviruses in animals and humans.

X Demographics

X Demographics

The data shown below were collected from the profiles of 75 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 278 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 <1%
Unknown 277 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 37 13%
Other 28 10%
Student > Ph. D. Student 27 10%
Student > Bachelor 24 9%
Student > Postgraduate 20 7%
Other 62 22%
Unknown 80 29%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 56 20%
Biochemistry, Genetics and Molecular Biology 31 11%
Agricultural and Biological Sciences 21 8%
Chemistry 20 7%
Medicine and Dentistry 18 6%
Other 47 17%
Unknown 85 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 149. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2024.
All research outputs
#276,031
of 25,397,764 outputs
Outputs from PLoS Pathogens
#184
of 9,477 outputs
Outputs of similar age
#5,016
of 315,042 outputs
Outputs of similar age from PLoS Pathogens
#4
of 182 outputs
Altmetric has tracked 25,397,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,477 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.3. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,042 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 182 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.