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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue
|
|---|---|
| Published in |
Gene Therapy, July 2012
|
| DOI | 10.1038/gt.2012.55 |
| Pubmed ID | |
| Authors |
F Mingozzi, Y Chen, S C Edmonson, S Zhou, R M Thurlings, P P Tak, K A High, M J Vervoordeldonk |
| Abstract |
Antibodies against adeno-associated viral (AAV) vectors are highly prevalent in humans. Both preclinical and clinical studies showed that antibodies against AAV block transduction even at low titers, particularly when the vector is introduced into the bloodstream. Here we measured the neutralizing antibody (NAb) titer against AAV serotypes 2, 5, 6 and 8 in the serum and matched synovial fluid (SF) from rheumatoid arthritis patients. The titer in the SF was lower than that in the matched plasma samples, indicating a difference in distribution of NAb to AAV depending on the body fluid compartment. This difference was more evident for AAV2, against which higher titers were measured. Of all serotypes, anti-AAV5 antibodies were the least prevalent in both the serum and SF. We next evaluated the impact of B-cell depletion on anti-AAV antibodies in rheumatoid arthritis patients who received one or two courses of the anti-CD20 antibody rituximab as part of their disease management. A drop of NAb titer was observed in a subset of those subjects carrying NAb titers ≤1:1000; however, only in a minority of subjects titers dropped below 1:5. This work provides insights into strategies to overcome the limitation of pre-existing humoral immunity to AAV vectors. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 107 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 28% |
| Student > Ph. D. Student | 23 | 21% |
| Other | 8 | 7% |
| Student > Master | 8 | 7% |
| Student > Doctoral Student | 6 | 5% |
| Other | 12 | 11% |
| Unknown | 22 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 22% |
| Biochemistry, Genetics and Molecular Biology | 22 | 20% |
| Medicine and Dentistry | 20 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Immunology and Microbiology | 6 | 5% |
| Other | 9 | 8% |
| Unknown | 23 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2024.
All research outputs
#2,676,291
of 23,394,907 outputs
Outputs from Gene Therapy
#382
of 3,010 outputs
Outputs of similar age
#17,589
of 165,568 outputs
Outputs of similar age from Gene Therapy
#5
of 20 outputs
Altmetric has tracked 23,394,907 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,010 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,568 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.