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Mendeley readers
Attention Score in Context
| Title |
Gray matter reduction associated with systemic chemotherapy for breast cancer: a prospective MRI study
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, August 2010
|
| DOI | 10.1007/s10549-010-1088-4 |
| Pubmed ID | |
| Authors |
Brenna C. McDonald, Susan K. Conroy, Tim A. Ahles, John D. West, Andrew J. Saykin |
| Abstract |
Brain gray matter alterations have been reported in cross-sectional magnetic resonance imaging (MRI) studies of breast cancer patients after cancer treatment. Here we report the first prospective MRI study of women undergoing treatment for breast cancer, with or without chemotherapy, as well as healthy controls. We hypothesized that chemotherapy-associated changes in gray matter density would be detectable 1 month after treatment, with partial recovery 1 year later. Participants included breast cancer patients treated with (CTx+, N = 17) or without (CTx-, N = 12) chemotherapy and matched healthy controls (N = 18). MRI scans were acquired at baseline (after surgery but before radiation, chemotherapy, and/or anti-estrogen treatment), 1 month after completion of chemotherapy (M1), and 1 year later (Y1). Voxel-based morphometry (VBM) was used to evaluate gray matter density differences between groups and over time. There were no between-group gray matter differences at baseline. Group-by-time interactions showed declines from baseline to M1 in both cancer groups relative to controls. Within-group analyses indicated that at M1 relative to baseline the CTx+ group had decreased gray matter density in bilateral frontal, temporal, and cerebellar regions and right thalamus. Recovery was seen at Y1 in some regions, although persistent decreases were also apparent. No significant within-group changes were found in the CTx- or control groups. Findings were not attributable to recency of cancer surgery, disease stage, psychiatric symptoms, psychotropic medication use, or hormonal treatment status. This study is the first to use a prospective, longitudinal approach to document decreased brain gray matter density shortly after breast cancer chemotherapy and its course of recovery over time. These gray matter alterations appear primarily related to the effects of chemotherapy, rather than solely reflecting host factors, the cancer disease process, or effects of other cancer treatments. |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Russia | 1 | <1% |
| France | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 167 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 19% |
| Researcher | 26 | 15% |
| Student > Master | 22 | 13% |
| Student > Doctoral Student | 13 | 8% |
| Student > Bachelor | 13 | 8% |
| Other | 31 | 18% |
| Unknown | 33 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 20% |
| Psychology | 35 | 20% |
| Neuroscience | 20 | 12% |
| Agricultural and Biological Sciences | 16 | 9% |
| Engineering | 7 | 4% |
| Other | 21 | 12% |
| Unknown | 37 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2012.
All research outputs
#20,165,369
of 22,675,759 outputs
Outputs from Breast Cancer Research and Treatment
#4,074
of 4,617 outputs
Outputs of similar age
#89,656
of 94,336 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#43
of 44 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,617 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,336 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.