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Neuropeptide Alterations in the Infundibular Nucleus of Huntington's Disease Patients

Overview of attention for article published in Journal of Neuroendocrinology, January 2013
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Title
Neuropeptide Alterations in the Infundibular Nucleus of Huntington's Disease Patients
Published in
Journal of Neuroendocrinology, January 2013
DOI 10.1111/j.1365-2826.2012.02379.x
Pubmed ID
Authors

D. J. van Wamelen, N. A. Aziz, J. J. Anink, R. A. C. Roos, D. F. Swaab

Abstract

Data from transgenic mouse models of Huntington's disease (HD) suggest that dysfunction of the hypothalamic infundibular nucleus (INF) (in rodents, the arcuate nucleus) may contribute to unintended weight loss and insatiable appetite among HD patients. Using post-mortem paraffin-embedded tissue, we assessed the total number of INF neurones by thionin staining and four major regulatory neuropeptides in the INF of HD patients by immunocytochemistry and in situ hybridisation. In HD patients, the total number of neurones in the INF was unchanged compared to control subjects (P = 0.92), whereas it contained over 30% less neuropeptide Y-immunoreactive (IR) neurones (P = 0.016), as well as reduced peptide levels, in fibres to the paraventricular and ventromedial nucleus (P = 0.003, P = 0.005, respectively). Conversely, neuropeptide Y mRNA expression levels were increased three-fold (P = 0.047). No changes were observed in the number of neurones immunoreactive for α-melanocyte-stimulating hormone, agouti-related peptide, and cocaine- and amphetamine-regulated transcript (P ≥ 0.17). Our findings suggest changes in the pathology of the INF neuropeptide Y-expressing neurones in HD patients without changes in other (an)orexigenic neuropeptides and without neuronal cell loss. These findings indicate that unintended weight loss in patients suffering from this disease may be partly a result of neuropeptidergic alterations in the hypothalamic infundibular nucleus.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 14%
Researcher 3 11%
Student > Bachelor 3 11%
Student > Ph. D. Student 3 11%
Student > Doctoral Student 2 7%
Other 8 29%
Unknown 5 18%
Readers by discipline Count As %
Neuroscience 5 18%
Medicine and Dentistry 4 14%
Agricultural and Biological Sciences 2 7%
Biochemistry, Genetics and Molecular Biology 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 5 18%
Unknown 9 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2012.
All research outputs
#16,900,730
of 24,851,605 outputs
Outputs from Journal of Neuroendocrinology
#867
of 1,350 outputs
Outputs of similar age
#193,155
of 291,946 outputs
Outputs of similar age from Journal of Neuroendocrinology
#7
of 12 outputs
Altmetric has tracked 24,851,605 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,350 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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