Title |
Family history of alcohol dependence modulates functional neurophysiology in mood/anxiety disorders
|
---|---|
Published in |
Psychological Medicine, October 2012
|
DOI | 10.1017/s003329171200222x |
Pubmed ID | |
Authors |
Z. Sjoerds, M.-J. van Tol, W. van den Brink, N. J. A. van der Wee, A. Aleman, A. T. F. Beekman, B. W. J. H. Penninx, D. J. Veltman |
Abstract |
A family history (FH) of alcohol dependence (AD) not only increases the risk for AD, but is also associated with an increased risk for mood and anxiety disorders. However, it is unknown how a FH of AD affects neural substrates in patients with mood and anxiety disorders. In this study we examined the effects of an alcoholic FH on cognitive and emotional functions in these patients using functional magnetic resonance imaging (fMRI). Method In a sample of non-alcoholic patients with depressive and/or anxiety disorders from the Netherlands Study of Depression and Anxiety (NESDA) neuroimaging study, patients with a first-degree FH of AD (FH + ; n = 31) were compared with patients without a FH (FH-; n = 77) on performance and brain activation during visuospatial planning and emotional word encoding. Results were compared with those of healthy controls (HCs) without a FH of AD (n = 31). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 3% |
Unknown | 70 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 17% |
Student > Master | 11 | 15% |
Researcher | 8 | 11% |
Student > Bachelor | 7 | 10% |
Student > Postgraduate | 6 | 8% |
Other | 14 | 19% |
Unknown | 14 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 27 | 38% |
Neuroscience | 10 | 14% |
Medicine and Dentistry | 9 | 13% |
Agricultural and Biological Sciences | 2 | 3% |
Mathematics | 1 | 1% |
Other | 5 | 7% |
Unknown | 18 | 25% |