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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Prospective Multicenter Study of Carbapenemase-Producing Enterobacteriaceae from 83 Hospitals in Spain Reveals High In Vitro Susceptibility to Colistin and Meropenem
|
|---|---|
| Published in |
Antimicrobial Agents and Chemotherapy, March 2015
|
| DOI | 10.1128/aac.00086-15 |
| Pubmed ID | |
| Authors |
Jesús Oteo, Adriana Ortega, Rosa Bartolomé, Germán Bou, Carmen Conejo, Marta Fernández-Martínez, Juan José González-López, Laura Martínez-García, Luis Martínez-Martínez, María Merino, Elisenda Miró, Marta Mora, Ferran Navarro, Antonio Oliver, Álvaro Pascual, Jesús Rodríguez-Baño, Guillermo Ruiz-Carrascoso, Patricia Ruiz-Garbajosa, Laura Zamorano, Verónica Bautista, María Pérez-Vázquez, José Campos |
| Abstract |
The aim of this study was to determine the impact of the carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2013 by describing their prevalence, dissemination and geographic distribution of CPE clones, their population structure and antibiotic susceptibility. From February 2013 to May 2013, 83 hospitals (about 40,000 hospital beds) prospectively collected non-duplicate Enterobacteriaceae using the screening cut-off recommended by EUCAST. Carbapenemase characterisation was performed by phenotypic methods and confirmed by PCR and sequencing. MLST types were determined for Klebsiella pneumoniae and Escherichia coli. A total of 702 Enterobacteriaceae isolates met the inclusion criteria; 379 (54%) were CPE. OXA-48 (71.5%) and VIM-1 (25.3%) were the most frequent carbapenemases, and K. pneumoniae (74.4%), Enterobacter cloacae (10.3%), and E. coli (8.4%) were the species most affected. Susceptibility to colistin, amikacin and meropenem was 95.5%, 81.3%, and 74.7%, respectively. The most prevalent STs were ST11 and ST405 in K. pneumoniae, and ST131 in E. coli. Forty-five (54.1%) of the hospitals had at least one CPE case. In K. pneumoniae, ST11/OXA-48, ST15/OXA-48, ST405/OXA-48, and ST11/VIM-1 were detected in two or more Spanish provinces. ST11 carried four carbapenemases (VIM-1, OXA-48, KPC-2, and OXA-245), but ST405 carried OXA-48 only. A wide interregional spread of CPE in Spain was observed mainly due to a few successful clones of OXA-48-producing K. pneumoniae (e.g. ST11 and ST405). Dissemination of OXA-48-producing E. coli is a new finding of public health concern. According to in vitro susceptibilities, most of the CPE (94.5%) had three or more options of antibiotic treatment. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 4 | 2% |
| Ireland | 1 | <1% |
| Unknown | 161 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 14% |
| Researcher | 22 | 13% |
| Student > Master | 21 | 13% |
| Other | 19 | 11% |
| Student > Doctoral Student | 15 | 9% |
| Other | 32 | 19% |
| Unknown | 33 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 39 | 23% |
| Immunology and Microbiology | 20 | 12% |
| Agricultural and Biological Sciences | 19 | 11% |
| Biochemistry, Genetics and Molecular Biology | 17 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 18 | 11% |
| Unknown | 48 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2016.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#14,745
of 15,579 outputs
Outputs of similar age
#239,768
of 278,145 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#177
of 218 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 15,579 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,145 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 218 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.