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Effectiveness of combined regional-general anesthesia for reducing mortality in coronary artery bypass: meta-analysis

Overview of attention for article published in Brazilian Journal of Anesthesiology, January 2016
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Title
Effectiveness of combined regional-general anesthesia for reducing mortality in coronary artery bypass: meta-analysis
Published in
Brazilian Journal of Anesthesiology, January 2016
DOI 10.1016/j.bjane.2014.05.012
Pubmed ID
Authors

Fabiano Timbó Barbosa, Rafael Martins da Cunha, Fernando Wagner da Silva Ramos, Fernando José Camello de Lima, Amanda Karine Barros Rodrigues, Ailton Mota do Nascimento Galvão, Célio Fernando de Sousa-Rodrigues, Paula Monique Barbosa Lima

Abstract

Neuraxial anesthesia (NA) has been used in association with general anesthesia (GA) for coronary artery bypass; however, anticoagulation during surgery makes us question the viability of benefits by the risk of epidural hematoma. The aim of this study was to perform a meta-analyzes examining the efficacy of NA associated with GA compared to GA alone for coronary artery bypass on mortality reduction. Mortality, arrhythmias, cerebrovascular accident (CVA), myocardial infarction (MI), length of hospital stay (LHS), length of ICU stay (ICUS), reoperations, blood transfusion (BT), quality of life, satisfaction degree, and postoperative cognitive dysfunction were analyzed. The weighted mean difference (MD) was estimated for continuous variables, and relative risk (RR) and risk difference (RD) for categorical variables. 17 original articles analyzed. Meta-analysis of mortality (RD=-0.01, 95% CI=-0.03 to 0.01), CVA (RR=0.79, 95% CI=0.32-1.95), MI (RR=0.96, 95% CI=0.52-1.79) and LHS (MD=-1.94, 95% CI=-3.99 to 0.12) were not statistically significant. Arrhythmia was less frequent with NA (RR=0.68, 95% CI=0.50-0.93). ICUS was lower in NA (MD=-2.09, 95% CI=-2.92 to -1.26). There was no significant difference in mortality. Combined NA and GA showed lower incidence of arrhythmias and lower ICUS.

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Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 18%
Other 6 18%
Researcher 6 18%
Student > Postgraduate 3 9%
Student > Master 3 9%
Other 4 12%
Unknown 6 18%
Readers by discipline Count As %
Medicine and Dentistry 16 47%
Nursing and Health Professions 4 12%
Psychology 3 9%
Immunology and Microbiology 1 3%
Environmental Science 1 3%
Other 2 6%
Unknown 7 21%