Title |
Transmission of lupus anticoagulant by allogeneic stem cell transplantation
|
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Published in |
Hematology Transfusion and Cell Therapy, May 2014
|
DOI | 10.1016/j.bjhh.2014.05.008 |
Pubmed ID | |
Authors |
Mira Romany Massoud, Basem M. William, Katrina Harrill, Brenda Wimpfheimer Cooper, Marcos de Lima, Alvin H. Schmaier |
Abstract |
Passive transmission of autoimmune diseases by allogeneic stem cell transplantation is rare and is ascribed to passive transfer of memory B-cells from donor to recipient. We hereby report a case of transmission of an asymptomatic lupus anticoagulant from a sibling donor to a recipient of transplantation for secondary acute myeloid leukemia. On pre-harvest evaluation, the sibling donor with no history of bleeding or thrombosis was found to have a lupus anticoagulant. After engraftment, the recipient was found to have a new prolonged activated partial thromboplastin time and was subsequently shown to have a lupus anticoagulant on Day +73 after stem cell transplantation. The recipient remained well with no evidence of bleeding, thrombosis, or graft-versus-host disease and was on a stable dose of tacrolimus at the time the lupus anticoagulant was detected. There was no other identifiable trigger for the appearance of a lupus anticoagulant. |
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Mendeley readers
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