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Haptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with sickle cell anemia

Overview of attention for article published in Hematology Transfusion and Cell Therapy, July 2015
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Title
Haptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with sickle cell anemia
Published in
Hematology Transfusion and Cell Therapy, July 2015
DOI 10.1016/j.bjhh.2015.07.006
Pubmed ID
Authors

Bruna Spinella Pierrot-Gallo, Perla Vicari, Sandra Satiko Matsuda, Samuel Ademola Adegoke, Grazielle Mecabo, Maria Stella Figueiredo

Abstract

Haptoglobin genotypes, and interleukin-6 and -8 participate in the pathophysiology of sickle cell anemia. The expression of cytokines is regulated by genetic mechanisms however the effect of haptoglobin polymorphisms on these cytokines is not fully understood. This study aimed to compare the frequency of haptoglobin genotypes and the interleukin-6 and -8 concentrations in sickle cell anemia patients and controls to investigate the association between haptoglobin genotypes and cytokine levels. Sixty sickle cell anemia patients and 74 healthy individuals were analyzed. Haptoglobin genotypes were determined by multiplex polymerase chain reaction, and the interleukin-6 and -8 levels by enzyme linked immunosorbent assay. The association between haptoglobin genotypes and cytokines was investigated by statistical tests. Hp2-1 was the most common genotype in both the cases and controls while Hp1-1 was less frequent among sickle cell anemia patients. Interleukin-6 and -8 levels were higher in patients than controls (p-value <0.0001). There was no significant difference in interleukin-6 and -8 concentrations between the genotypes (p-value >0.05). A similar trend was observed among the controls. Although, levels of interleukin-6 and -8 were higher in the sickle cell anemia patients, they appeared not to be related to the haptoglobin genotypes. Further investigations are necessary to identify factors responsible for increased secretion of the interleukin-6 and -8 pro-inflammatory cytokines in patients with sickle cell anemia.

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The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Algeria 1 2%
Unknown 45 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 20%
Student > Bachelor 8 17%
Student > Postgraduate 6 13%
Researcher 4 9%
Student > Ph. D. Student 3 7%
Other 5 11%
Unknown 11 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 22%
Medicine and Dentistry 8 17%
Biochemistry, Genetics and Molecular Biology 6 13%
Nursing and Health Professions 4 9%
Veterinary Science and Veterinary Medicine 1 2%
Other 2 4%
Unknown 15 33%