Title |
High prevalence and incidence of HIV-1 in a counseling and testing center in the city of Itajaí, Brazil
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Published in |
Brazilian Journal of Infectious Diseases, September 2015
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DOI | 10.1016/j.bjid.2015.08.001 |
Pubmed ID | |
Authors |
Gorki Grinberg, Leila Bertoni Giron, Rosalie Kupka Knoll, Juliana Galinskas, Michelle Camargo, Muhammad Shoaib Arif, Sadia Samer, Luiz Mario Ramos Janini, Maria Cecilia Araripe Sucupira, Ricardo Sobhie Diaz |
Abstract |
Itajaí is a port city in southern Brazil with one of the highest incidence and mortality rates from AIDS in the country. The prevalence and incidence of HIV infection were investigated in 1085 of 3196 new HIV-1 infection cases evaluated in the counseling and testing center (CTC) of Itajaí from January 2002 to August 2008. Recent infections were assessed using the BED™, and pol region sequencing was performed in 76 samples. The prevalence ranged from 3.08% to 6.17% among women and from 10.26% to 17.36% among men. A total of 17% of infections were classified as recent (RI), with annual incidence varying from 1.6% to 4.8 per 100 PY among women and from 2.05% to 8.5 per 100 PY among men. Pol sequences were obtained from 38 randomly RI selected individuals: 71% were infected by subtype C, 24% B, 2% D, and 2% F1. Among 38 subjects with established infection (EI), 76% were subtype C, and 24% B. Transmitted drug resistance (TDR) was detected in 18.4% of RI subjects (7.8% to NRTI, 5.2% to NNRTI, and 5.2% PIs) and 5.2% of subjects with EI had NRTI resistance. The high prevalence and incidence of HIV infection in this region is unprecedented in studies involving cases evaluated in CTCs in Brazil. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 18% |
Student > Bachelor | 6 | 18% |
Student > Ph. D. Student | 4 | 12% |
Student > Doctoral Student | 3 | 9% |
Lecturer | 2 | 6% |
Other | 5 | 15% |
Unknown | 8 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 29% |
Nursing and Health Professions | 4 | 12% |
Social Sciences | 2 | 6% |
Agricultural and Biological Sciences | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 3 | 9% |
Unknown | 12 | 35% |