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| Title |
Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and anti-HBs
|
|---|---|
| Published in |
Brazilian Journal of Infectious Diseases, November 2015
|
| DOI | 10.1016/j.bjid.2015.08.014 |
| Pubmed ID | |
| Authors |
Feng Ding, Xi-Li Miao, Yan-Xia Li, Jin-Fen Dai, Hong-Gang Yu |
| Abstract |
The mechanism underlying the coexistence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) in chronic hepatitis B (CHB) patients remains unknown. This research aimed to determine the clinical and virological features of the rare pattern. A total of 32 CHB patients infected by HBV genotype C were included: 15 carrying both HBsAg and anti-HBs (group I) and 17 solely positive for HBsAg (group II). S gene and reverse transcriptase (RT) region sequences were amplified, sequenced and compared with the reference sequences. The amino acid (aa) variability within major hydrophilic region (MHR), especially the "a" determinant region, and within RT for regions overlapping the MHR in group I is significantly higher than those in group II. Mutation sI126S/T within the "a" determinant was the most frequent change, and only patients from group I had the sQ129R, sG130N, sF134I, sG145R aa changes, which are known to alter immunogenicity. In CHB patients, the concurrent HBsAg/anti-HBs serological profile is associated with an increased aa variability in several key areas of HBV genome. Additional research on these genetic mutants are needed to clarify their biological significance for viral persistence. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 14% |
| Researcher | 3 | 14% |
| Student > Ph. D. Student | 3 | 14% |
| Student > Postgraduate | 2 | 9% |
| Student > Master | 2 | 9% |
| Other | 1 | 5% |
| Unknown | 8 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 32% |
| Agricultural and Biological Sciences | 4 | 18% |
| Medicine and Dentistry | 3 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Unknown | 7 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2016.
All research outputs
#23,154,082
of 25,806,080 outputs
Outputs from Brazilian Journal of Infectious Diseases
#646
of 812 outputs
Outputs of similar age
#337,747
of 395,228 outputs
Outputs of similar age from Brazilian Journal of Infectious Diseases
#13
of 20 outputs
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So far Altmetric has tracked 812 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.