Title |
Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease
|
---|---|
Published in |
Brazilian Journal of Infectious Diseases, November 2015
|
DOI | 10.1016/j.bjid.2015.09.005 |
Pubmed ID | |
Authors |
Ji Young Hong, Sun Hee Jang, Song Yee Kim, Kyung Soo Chung, Joo Han Song, Moo Suk Park, Young Sam Kim, Kyu Kim, Joon Chang, Young Ae Kang |
Abstract |
Increased serum CA 19-9 levels in patients with nonmalignant diseases have been investigated in previous reports. This study evaluates the clinical significance of serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial (PNTM) disease and pulmonary tuberculosis (TB). The median CA 19-9 level was higher in patients with PNTM disease than in patients with pulmonary TB (PNTM: 13.80, TB: 5.85, p<0.001). A multivariate logistic regression analysis performed in this study showed that Mycobacterium abscessus (OR 9.97, 95% CI: 1.58, 62.80; p=0.014) and active phase of PNTM disease (OR 12.18, 95% CI: 1.07, 138.36, p=0.044) were found to be risk factors for serum CA 19-9 elevation in PNTM disease. The serum CA 19-9 levels showed a tendency to decrease during successful treatment of PNTM disease but not in pulmonary TB. These findings suggest that CA 19-9 may be a useful marker for monitoring therapeutic responses in PNTM disease, although it is not PNTM disease-specific marker. |
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