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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against Histoplasma capsulatum strains in vitro
|
|---|---|
| Published in |
Brazilian Journal of Infectious Diseases, December 2015
|
| DOI | 10.1016/j.bjid.2015.11.003 |
| Pubmed ID | |
| Authors |
Raimunda Sâmia Nogueira Brilhante, Érica Pacheco Caetano, Giovanna Barbosa Riello, Glaucia Morgana de Melo Guedes, Débora de Souza Collares Maia Castelo-Branco, Maria Auxiliadora Bezerra Fechine, Jonathas Sales de Oliveira, Zoilo Pires de Camargo, Jacó Ricarte Lima de Mesquita, André Jalles Monteiro, Rossana de Aguiar Cordeiro, Marcos Fábio Gadelha Rocha, José Júlio Costa Sidrim |
| Abstract |
Recent studies have shown that some drugs that are not routinely used to treat fungal infections have antifungal activity, such as protease inhibitor antiretroviral drugs. This study investigated the in vitro susceptibility of Histoplasma capsulatum var. capsulatum to saquinavir and ritonavir, and its combination with the antifungal itraconazole. The susceptibility assay was performed according to CSLI guidelines. All strains were inhibited by the protease inhibitor antiretroviral drugs. Saquinavir showed MICs ranging from 0.125 to 1μgmL(-1) for both phases, and ritonavir presented MICs ranging from 0.0312 to 4μgmL(-1)and from 0.0625 to 1μgmL(-1) for filamentous and yeast phase, respectively. Concerning the antifungal itraconazole, the MIC values ranged from 0.0019 to 0.125μgmL(-1) and from 0.0039 to 0.0312μgmL(-1) for the filamentous and yeast phase, respectively. The combination of saquinavir or ritonavir with itraconazole was synergistic against H. capsulatum, with a significant reduction in the MICs of both drugs against the strains (p<0.05). These data show an important in vitro synergy between protease inhibitors and itraconazole against the fungus H. capsulatum. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 33% |
| France | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 21% |
| Student > Postgraduate | 4 | 14% |
| Student > Ph. D. Student | 4 | 14% |
| Student > Doctoral Student | 2 | 7% |
| Student > Master | 2 | 7% |
| Other | 3 | 11% |
| Unknown | 7 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 29% |
| Biochemistry, Genetics and Molecular Biology | 4 | 14% |
| Agricultural and Biological Sciences | 3 | 11% |
| Immunology and Microbiology | 2 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
| Other | 3 | 11% |
| Unknown | 6 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2016.
All research outputs
#17,286,379
of 25,374,917 outputs
Outputs from Brazilian Journal of Infectious Diseases
#405
of 809 outputs
Outputs of similar age
#242,147
of 399,216 outputs
Outputs of similar age from Brazilian Journal of Infectious Diseases
#9
of 26 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 809 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 399,216 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.