Title |
JC virus/human immunodeficiency virus 1 co-infection in the Brazilian Amazonian region
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Published in |
Brazilian Journal of Infectious Diseases, June 2016
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DOI | 10.1016/j.bjid.2016.05.005 |
Pubmed ID | |
Authors |
Izaura Maria Vieira Cayres-Vallinoto, Antonio Carlos Rosário Vallinoto, Giselle Priscila dos Anjos Pena, Vânia Nakauth Azevedo, Luiz Fernando Almeida Machado, Marluísa de Oliveira Guimarães Ishak, Ricardo Ishak |
Abstract |
JC virus (JCV) is a member of the Polyomaviridae family and is associated to a severe disease known as progressive multifocal leukoencephalopathy, PML, which is gradually increasing in incidence as an opportunistic infection among AIDS patients. The present study aimed to investigate the occurrence of JCV among HIV-1 carriers including their types and molecular subtypes and the possible association with disease. Urine samples from 66 HIV-1 infected subjects were investigated for the presence of the virus by amplifying VP1 (215bp) and IG (610bp) regions using the polymerase chain reaction. JCV was detected in 32% of the samples. The results confirmed the occurrence of type B (subtype Af2); in addition, another polyomavirus, BKV, was also detected in 1.5% of samples of the HIV-1 infected subjects. Apparently, there was no significant difference between mono- (HIV-1 only) and co-infected (HIV-1/JCV) subjects regarding their TCD4(+)/TCD8(+) lymphocyte counts or HIV-1 plasma viral load. Self admitted seizures, hearing and visual loses were not significantly different between the two groups. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 3% |
Unknown | 28 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 21% |
Student > Bachelor | 5 | 17% |
Student > Postgraduate | 3 | 10% |
Other | 2 | 7% |
Professor > Associate Professor | 2 | 7% |
Other | 4 | 14% |
Unknown | 7 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 21% |
Biochemistry, Genetics and Molecular Biology | 4 | 14% |
Immunology and Microbiology | 3 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Agricultural and Biological Sciences | 2 | 7% |
Other | 2 | 7% |
Unknown | 10 | 34% |