Title |
Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis
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Published in |
Brazilian Journal of Infectious Diseases, December 2016
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DOI | 10.1016/j.bjid.2016.11.005 |
Pubmed ID | |
Authors |
Cynthia Azeredo Cordeiro, Erica Leandro Marciano Vieira, Natália Pessoa Rocha, Vinicius Monteiro Castro, Juliana Lambert Oréfice, Tatiana Barichello, Rogerio Alves Costa, Fernando Oréfice, Lucy Young, Antonio Lucio Teixeira |
Abstract |
Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment. Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay. BDNF levels were significantly higher in patients before treatment when compared with controls (p=0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors. BDNF may be released in the context of the active TR inflammatory response. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 24% |
Researcher | 5 | 20% |
Student > Ph. D. Student | 4 | 16% |
Student > Bachelor | 3 | 12% |
Professor | 3 | 12% |
Other | 2 | 8% |
Unknown | 2 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 20% |
Agricultural and Biological Sciences | 4 | 16% |
Immunology and Microbiology | 3 | 12% |
Environmental Science | 2 | 8% |
Nursing and Health Professions | 1 | 4% |
Other | 6 | 24% |
Unknown | 4 | 16% |