You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transmitted drug resistance in patients with acute/recent HIV infection in Brazil
|
|---|---|
| Published in |
Brazilian Journal of Infectious Diseases, May 2017
|
| DOI | 10.1016/j.bjid.2017.03.013 |
| Pubmed ID | |
| Authors |
Ana Cristina G. Ferreira, Lara E. Coelho, Eduarda Grinsztejn, Carlos S. de Jesus, Monick L. Guimarães, Valdiléa G. Veloso, Beatriz Grinsztejn, Sandra W. Cardoso |
| Abstract |
The widespread use of antiretroviral therapy (ART) increased the transmission of antiretroviral resistant HIV strains. ART initiation during acute/recent HIV infection limits HIV reservoirs and improves immune response in HIV infected individuals. Transmitted drug resistance (TDR) may jeopardize the early goals of early ART among acute/recent HIV infected patients. Patients with acute/recent HIV infection who underwent resistance test before ART initiation were included in this analysis. HIV-1 sequences were obtained using an in house protease/reverse transcriptase genotyping assay. TDR was identified according to the Stanford HIV Database for Transmitted Drug Resistance Mutations, based on WHO 2009 surveillance list, and HIV-1 subtyping according to Rega HIV-1 subtyping tool. Comparison between patients with and without TDR was made using Kruskal-Wallis and Chi-square tests. Forty-three patients were included, 13 with acute HIV infection and 30 with recent HIV infection. The overall TDR prevalence was 16.3% (95% confidence interval [CI]: 8.1-30.0%). The highest prevalence of resistance (11.6%, 95% CI: 8.1-24.5) was against non-nucleoside reverse transcriptase inhibitors (NNRTI), and K103N was the most frequently identified mutation. The high prevalence of NNRTI resistance indicates that efavirenz-based regimen without prior resistance testing is not ideal for acutely/recently HIV-infected individuals in our setting. In this context, the recent proposal of including integrase inhibitors as a first line ART regimen in Brazil could be an advantage for the treatment of newly HIV infected individuals. However, it also poses a new challenge, since integrase resistance test is not routinely performed for ART naive individuals. Further studies on TDR among acutely/recently HIV-infected are needed to inform on predictors of TDR and ART outcomes among these population. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 73 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 21% |
| Student > Bachelor | 9 | 12% |
| Student > Ph. D. Student | 7 | 10% |
| Student > Doctoral Student | 6 | 8% |
| Student > Postgraduate | 6 | 8% |
| Other | 13 | 18% |
| Unknown | 17 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 18% |
| Biochemistry, Genetics and Molecular Biology | 10 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 10% |
| Agricultural and Biological Sciences | 7 | 10% |
| Immunology and Microbiology | 5 | 7% |
| Other | 11 | 15% |
| Unknown | 20 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2017.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Brazilian Journal of Infectious Diseases
#646
of 809 outputs
Outputs of similar age
#285,961
of 326,701 outputs
Outputs of similar age from Brazilian Journal of Infectious Diseases
#14
of 15 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 809 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,701 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.