Title |
DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population
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Published in |
Brazilian Journal of Microbiology, March 2016
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DOI | 10.1016/j.bjm.2015.09.001 |
Pubmed ID | |
Authors |
Ronaldo Celerino da Silva, Heidi Lacerda Alves da Cruz, Lucas André Cavalcanti Brandão, Rafael Lima Guimarães, Lilian Maria Lapa Montenegro, Haiana Charifker Schindler, Ludovica Segat, Sergio Crovella |
Abstract |
β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G>A (rs1799946), -44C>G (rs1800972) and -20G>A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 15% |
Researcher | 4 | 15% |
Student > Bachelor | 3 | 12% |
Professor | 3 | 12% |
Student > Doctoral Student | 2 | 8% |
Other | 6 | 23% |
Unknown | 4 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 23% |
Medicine and Dentistry | 6 | 23% |
Nursing and Health Professions | 3 | 12% |
Immunology and Microbiology | 1 | 4% |
Unknown | 10 | 38% |