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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Azole resistance in Candida spp. isolated from Catú Lake, Ceará, Brazil: an efflux-pump-mediated mechanism
|
|---|---|
| Published in |
Brazilian Journal of Microbiology, January 2016
|
| DOI | 10.1016/j.bjm.2015.11.008 |
| Pubmed ID | |
| Authors |
Raimunda S.N. Brilhante, Manoel A.N. Paiva, Célia M.S. Sampaio, Débora S.C.M. Castelo-Branco, Carlos E.C. Teixeira, Lucas P. de Alencar, Tereza J.P.G. Bandeira, André J. Monteiro, Rossana A. Cordeiro, Waldemiro A. Pereira-Neto, José J.C. Sidrim, José L.B. Moreira, Marcos F.G. Rocha |
| Abstract |
Since, there is no study reporting the mechanism of azole resistance among yeasts isolated from aquatic environments; the present study aims to investigate the occurrence of antifungal resistance among yeasts isolated from an aquatic environment, and assess the efflux-pump activity of the azole-resistant strains to better understand the mechanism of resistance for this group of drugs. For this purpose, monthly water and sediment samples were collected from Catú Lake, Ceará, Brazil, from March 2011 to February 2012. The obtained yeasts were identified based on morphological and biochemical characteristics. Of the 46 isolates, 37 were Candida spp., 4 were Trichosporon asahii, 3 were Cryptococcus laurentii, 1 Rhodotorula mucilaginosa, and 1 was Kodamaea ohmeri. These isolates were subjected to broth microdilution assay with amphotericin B, itraconazole, and fluconazole, according to the methodology standardized by the Clinical and Laboratory Standards Institute (CLSI). The minimum inhibitory concentrations (MICs) of amphotericin B, itraconazole, and fluconazole were 0.03125-2μg/mL, 0.0625 to ≥16μg/mL, and 0.5 to ≥64μg/mL, respectively, and 13 resistant azole-resistant Candida isolates were detected. A reduction in the azole MICs leading to the phenotypical reversal of the azole resistance was observed upon addition of efflux-pump inhibitors. These findings suggest that the azole resistance among environmental Candida spp. is most likely associated with the overexpression of efflux-pumps. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 60 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 23% |
| Student > Master | 8 | 13% |
| Student > Ph. D. Student | 6 | 10% |
| Researcher | 5 | 8% |
| Student > Doctoral Student | 4 | 7% |
| Other | 10 | 17% |
| Unknown | 13 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 17% |
| Biochemistry, Genetics and Molecular Biology | 10 | 17% |
| Medicine and Dentistry | 8 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 10% |
| Immunology and Microbiology | 6 | 10% |
| Other | 7 | 12% |
| Unknown | 13 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2016.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Brazilian Journal of Microbiology
#887
of 1,377 outputs
Outputs of similar age
#299,937
of 405,739 outputs
Outputs of similar age from Brazilian Journal of Microbiology
#21
of 40 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,377 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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