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Inactivation of MarR gene homologs increases susceptibility to antimicrobials in Bacteroides fragilis

Overview of attention for article published in Brazilian Journal of Microbiology, August 2017
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Title
Inactivation of MarR gene homologs increases susceptibility to antimicrobials in Bacteroides fragilis
Published in
Brazilian Journal of Microbiology, August 2017
DOI 10.1016/j.bjm.2017.05.005
Pubmed ID
Authors

Clara Maria Guimarães Silva, Déborah Nascimento dos Santos Silva, Scarlathe Bezerra da Costa, Juliana Soares de Sá Almeida, Renata Ferreira Boente, Felipe Lopes Teixeira, Regina Maria Cavalcanti Pilotto Domingues, Leandro Araujo Lobo

Abstract

Bacteroides fragilis is the strict anaerobic bacteria most commonly found in human infections, and has a high mortality rate. Among other virulence factors, the remarkable ability to acquire resistance to a variety of antimicrobial agents and to tolerate nanomolar concentrations of oxygen explains in part their success in causing infection and colonizing the mucosa. Much attention has been given to genes related to multiple drug resistance derived from plasmids, integrons or transposon, but such genes are also detected in chromosomal systems, like the mar (multiple antibiotic resistance) locus, that confer resistance to a range of drugs. Regulators like MarR, that control expression of the locus mar, also regulate resistance to organic solvents, disinfectants and oxygen reactive species are important players in these events. Strains derived from the parental strain 638R, with mutations in the genes hereby known as marRI (BF638R_3159) and marRII (BF638R_3706) were constructed by gene disruption using a suicide plasmid. Phenotypic response of the mutant strains to hydrogen peroxide, cell survival assay against exposure to oxygen, biofilm formation, resistance to bile salts and resistance to antibiotics was evaluated. The results showed that the mutant strains exhibit statistically significant differences in their response to oxygen stress, but no changes were observed in survival when exposed to bile salts. Biofilm formation was not affected by either gene disruption. Both mutant strains however, became more sensitive to multiple antimicrobial drugs tested. This indicates that as observed in other bacterial species, MarR are an important resistance mechanism in B. fragilis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 15%
Researcher 5 13%
Student > Ph. D. Student 5 13%
Student > Doctoral Student 3 8%
Student > Bachelor 3 8%
Other 5 13%
Unknown 12 31%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 15%
Immunology and Microbiology 6 15%
Medicine and Dentistry 5 13%
Veterinary Science and Veterinary Medicine 2 5%
Agricultural and Biological Sciences 1 3%
Other 6 15%
Unknown 13 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2017.
All research outputs
#16,051,091
of 25,382,440 outputs
Outputs from Brazilian Journal of Microbiology
#478
of 1,377 outputs
Outputs of similar age
#185,888
of 327,653 outputs
Outputs of similar age from Brazilian Journal of Microbiology
#6
of 20 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,377 research outputs from this source. They receive a mean Attention Score of 3.6. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,653 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.