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Elastin increases biofilm and extracellular matrix production of Aspergillus fumigatus

Overview of attention for article published in Brazilian Journal of Microbiology, February 2018
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Title
Elastin increases biofilm and extracellular matrix production of Aspergillus fumigatus
Published in
Brazilian Journal of Microbiology, February 2018
DOI 10.1016/j.bjm.2017.10.004
Pubmed ID
Authors

Ildnay de Souza Lima Brandão, Heloiza Maria da Silva Oliveira-Moraes, Cristina Maria de Souza Motta, Neiva Tinti de Oliveira, Oliane Maria Correia Magalhães

Abstract

Aspergillus fumigatus is an opportunistic saprobe fungus that accounts for 90% of cases of pulmonary aspergillosis in immunosuppressed patients and is known for its angiotropism. When it reaches the respiratory tract, A. fumigatus interacts with structural components and blood vessels of the lungs, such as elastin. To understand the effect of this structural component, we examined the effect of elastin on the production and development of the biofilm of A. fumigatus. In RPMI containing 10mg/mL of elastin, a significant increase (absorbance p<0.0001; dry weight p<0.0001) in the production of biofilm was observed in comparison to when RPMI was used alone, reaching a maximum growth of 18.8mg (dry weight) of biofilm in 72h. In addition, elastin stimulates the production (p=0.0042) of extracellular matrix (ECM) and decreases (p=0.005) the hydrophobicity during the development of the biofilm. These results suggest that elastin plays an important role in the growth of A. fumigatus and that it participates in the formation of thick biofilm.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 62 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 10%
Student > Ph. D. Student 4 6%
Other 3 5%
Researcher 3 5%
Student > Master 3 5%
Other 2 3%
Unknown 41 66%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 13%
Agricultural and Biological Sciences 3 5%
Immunology and Microbiology 3 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Mathematics 1 2%
Other 6 10%
Unknown 40 65%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2018.
All research outputs
#20,663,600
of 25,382,440 outputs
Outputs from Brazilian Journal of Microbiology
#887
of 1,377 outputs
Outputs of similar age
#348,506
of 455,271 outputs
Outputs of similar age from Brazilian Journal of Microbiology
#16
of 25 outputs
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So far Altmetric has tracked 1,377 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.