Title |
Elastin increases biofilm and extracellular matrix production of Aspergillus fumigatus
|
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Published in |
Brazilian Journal of Microbiology, February 2018
|
DOI | 10.1016/j.bjm.2017.10.004 |
Pubmed ID | |
Authors |
Ildnay de Souza Lima Brandão, Heloiza Maria da Silva Oliveira-Moraes, Cristina Maria de Souza Motta, Neiva Tinti de Oliveira, Oliane Maria Correia Magalhães |
Abstract |
Aspergillus fumigatus is an opportunistic saprobe fungus that accounts for 90% of cases of pulmonary aspergillosis in immunosuppressed patients and is known for its angiotropism. When it reaches the respiratory tract, A. fumigatus interacts with structural components and blood vessels of the lungs, such as elastin. To understand the effect of this structural component, we examined the effect of elastin on the production and development of the biofilm of A. fumigatus. In RPMI containing 10mg/mL of elastin, a significant increase (absorbance p<0.0001; dry weight p<0.0001) in the production of biofilm was observed in comparison to when RPMI was used alone, reaching a maximum growth of 18.8mg (dry weight) of biofilm in 72h. In addition, elastin stimulates the production (p=0.0042) of extracellular matrix (ECM) and decreases (p=0.005) the hydrophobicity during the development of the biofilm. These results suggest that elastin plays an important role in the growth of A. fumigatus and that it participates in the formation of thick biofilm. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 6 | 10% |
Student > Ph. D. Student | 4 | 6% |
Other | 3 | 5% |
Researcher | 3 | 5% |
Student > Master | 3 | 5% |
Other | 2 | 3% |
Unknown | 41 | 66% |
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Immunology and Microbiology | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Mathematics | 1 | 2% |
Other | 6 | 10% |
Unknown | 40 | 65% |