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Hearing function after betahistine therapy in patients with Ménière's disease

Overview of attention for article published in Brazilian Journal of Otorhinolaryngology, December 2015
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Title
Hearing function after betahistine therapy in patients with Ménière's disease
Published in
Brazilian Journal of Otorhinolaryngology, December 2015
DOI 10.1016/j.bjorl.2015.08.021
Pubmed ID
Authors

Seyed Javad Seyed Tootoonchi, Samad Ghiasi, Parvaneh Shadara, Simin Mirakhor Samani, Daniel Fadaei Fouladi

Abstract

Preventing or reversing hearing loss is challenging in Ménière's disease. Betahistine, as a histamine agonist, has been tried in controlling vertigo in patients with Ménière's disease, but its effectiveness on hearing problems is not known. To examine the effect of betahistine on hearing function in not-previously-treated patients with Ménière's disease and to define possible contributors in this regard. A total of 200 not-previously-treated patients with definite unilateral Ménière's disease received betahistine by mouth (initial dose, 16mg three times a day; maintenance dose, 24-48mg daily in divided doses). Changes in indicators of hearing status before and six months after treatment were documented. Hearing loss was considered as the mean hearing level >25dB HL at five frequencies. The mean duration of disease was 3.37 years. Six months after treatment the mean hearing level decreased by 6.35dB compared to that at the baseline (p<0.001). Both patients' age and the duration of disease correlated negatively with the improvement in hearing function. Post treatment hearing loss was independently associated with age, the initial hearing level and the chronicity of disease. The corresponding optimal cut-off points for predicating a persistent hearing loss 6 months after treatment were 47 years, 38dB HL, and 1.4 years, respectively. Oral betahistine was significantly effective in preventing/reversing hearing deterioration in patients with Ménière's disease. Age, the hearing level on admission, and the disease duration were independent predictors of hearing status after treatment.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 25%
Student > Bachelor 3 19%
Researcher 2 13%
Student > Doctoral Student 1 6%
Professor > Associate Professor 1 6%
Other 1 6%
Unknown 4 25%
Readers by discipline Count As %
Medicine and Dentistry 8 50%
Agricultural and Biological Sciences 1 6%
Nursing and Health Professions 1 6%
Neuroscience 1 6%
Engineering 1 6%
Other 0 0%
Unknown 4 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2016.
All research outputs
#15,739,529
of 25,373,627 outputs
Outputs from Brazilian Journal of Otorhinolaryngology
#329
of 726 outputs
Outputs of similar age
#209,217
of 394,029 outputs
Outputs of similar age from Brazilian Journal of Otorhinolaryngology
#12
of 26 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 726 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 394,029 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.