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X Demographics
Mendeley readers
| Title |
The effect of central nervous system depressant, stimulant and hallucinogenic drugs on injury severity in patients admitted for trauma
|
|---|---|
| Published in |
Gaceta Sanitaria, August 2017
|
| DOI | 10.1016/j.gaceta.2017.06.006 |
| Pubmed ID | |
| Authors |
Sergio Cordovilla-Guardia, Pablo Lardelli-Claret, Raquel Vilar-López, Fidel López-Espuela, Francisco Guerrero-López, Enrique Fernández-Mondéjar |
| Abstract |
The effect of drugs other than alcohol on severity of trauma remains unclear. Pooled data analyses in previous studies that grouped substances with opposite effects on the central nervous system (CNS) may have masked the influence of substances on injury severity. The aim was to analyze the effect of stimulant, hallucinogenic and depressant drugs other than alcohol on injury severity in trauma patients. The presence of alcohol, stimulant drugs (cocaine, amphetamines and methamphetamines), depressant drugs (benzodiazepines, opiates, methadone and barbiturates) and hallucinogenic drugs (THC and PCP) was analyzed in 1187 patients between 16 and 70 years old admitted to a trauma hospital between November 2012 and June 2015. Injury severity was determined prospectively as the Injury Severity Score. A multivariate analysis was used to quantify the strength of association between exposure to substances and trauma severity, using the presence of alcohol as a stratification variable. Drugs other than alcohol were found in 371 patients (31.3%): 32 (2.7%) stimulants, 186 (15.3%) depressants, 78 (6.6%) hallucinogenics and 75 (5.6%) polydrug use. The presence of CNS depressant substances was associated with increased injury severity only in patients also exposed to alcohol, with an adjusted odds ratio of 4.63 (1.37-15.60) for moderate injuries and 7.83 (2.53-24.21) for severe. CNS depressant drugs had a strong influence on injury severity in patients who screened positive for alcohol consumption. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 18% |
| Researcher | 10 | 13% |
| Student > Master | 6 | 8% |
| Student > Ph. D. Student | 4 | 5% |
| Lecturer | 3 | 4% |
| Other | 12 | 15% |
| Unknown | 30 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 14% |
| Nursing and Health Professions | 9 | 11% |
| Psychology | 6 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Other | 10 | 13% |
| Unknown | 32 | 41% |