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Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children

Overview of attention for article published in Jornal de Pediatria, August 2017
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Title
Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children
Published in
Jornal de Pediatria, August 2017
DOI 10.1016/j.jped.2017.03.007
Pubmed ID
Authors

Mudasir Nazir, Wasim Ahmad Wani, Muzaffar Ahmad Malik, Mohd Rafiq Mir, Younis Ashraf, Khalid Kawoosa, Syed Wajid Ali

Abstract

To assess the performance of cerebrospinal fluid (CSF) lactate as a biomarker to differentiate bacterial meningitis (BM) from viral meningitis (VM) in children, and to define an optimal CSF lactate concentration that can be called significant for the differentiation. Children with clinical findings compatible with meningitis were studied. CSF lactate and other conventional CSF parameters were recorded. At a cut-off value of 3mmol/L, CSF lactate had a sensitivity of 0.90, specificity of 1.0, positive predictive value of 1.0, and negative predictive value of 0.963, with an accuracy of 0.972. The positive and negative likelihood ratios were 23.6 and 0.1, respectively. When comparing between BM and VM, the area under the curve (AUC) for CSF lactate was 0.979. The authors concluded that CSF lactate has high sensitivity and specificity in differentiating bacterial from viral meningitis. While at a cut-off value of 3mmol/L, CSF lactate has high diagnostic accuracy for BM, mean levels in VM remain essentially below 2mmol/L.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 88 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 18%
Student > Ph. D. Student 10 11%
Student > Master 6 7%
Student > Postgraduate 5 6%
Other 5 6%
Other 13 15%
Unknown 33 38%
Readers by discipline Count As %
Medicine and Dentistry 26 30%
Biochemistry, Genetics and Molecular Biology 9 10%
Agricultural and Biological Sciences 3 3%
Immunology and Microbiology 3 3%
Chemistry 2 2%
Other 11 13%
Unknown 34 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2017.
All research outputs
#20,663,600
of 25,382,440 outputs
Outputs from Jornal de Pediatria
#644
of 896 outputs
Outputs of similar age
#250,758
of 323,499 outputs
Outputs of similar age from Jornal de Pediatria
#32
of 38 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 896 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.