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Refractory Celiac Disease Type II: A Case Report that Demonstrates the Diagnostic and Therapeutic Challenges

Overview of attention for article published in GE-Portuguese Journal of Gastroenterology, September 2015
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Title
Refractory Celiac Disease Type II: A Case Report that Demonstrates the Diagnostic and Therapeutic Challenges
Published in
GE-Portuguese Journal of Gastroenterology, September 2015
DOI 10.1016/j.jpge.2015.08.001
Pubmed ID
Authors

Alexandra Fernandes, Ana Margarida Ferreira, Rosa Ferreira, Sofia Mendes, Cláudia Agostinho, Nuno Almeida, Pedro Figueiredo, Manuela Ferreira, Pedro Amaro, Lígia Prado e Castro, Carlos Sofia

Abstract

Refractory celiac disease is an uncommon but serious complication of celiac disease. We describe a case of a severe refractory celiac disease type II, complicated with ulcerative jejunoileitis, in a 68 years old female, unresponsive to consecutive treatments with budesonide, prednisolone, cladribine and autologous stem cell transplantation. The patient maintained severe malnutrition, advanced osteoporosis, anaemia, vitamin deficiencies and hydro-electrolytic imbalances, necessitating consecutive hospitalizations for total parenteral nutrition. The patient also developed life-threatening complications, namely respiratory and urinary septic shock and also episodes of haemorrhagic shock secondary to ulcerative jejunoileitis. The progression to enteropathy associated T-cell lymphoma was never demonstrated, but the patient died 7 years after the diagnosis due to a septic shock secondary to a nosocomial pneumonia and osteomyelitis related to a spontaneous hip fracture. This case highlights the difficulties in the diagnostic process, therapeutic management and surveillance of this rare condition associated with very poor prognosis.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 22%
Student > Master 4 17%
Lecturer 2 9%
Other 2 9%
Student > Ph. D. Student 2 9%
Other 4 17%
Unknown 4 17%
Readers by discipline Count As %
Medicine and Dentistry 5 22%
Nursing and Health Professions 4 17%
Agricultural and Biological Sciences 2 9%
Biochemistry, Genetics and Molecular Biology 2 9%
Veterinary Science and Veterinary Medicine 1 4%
Other 5 22%
Unknown 4 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2015.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from GE-Portuguese Journal of Gastroenterology
#69
of 198 outputs
Outputs of similar age
#171,625
of 286,826 outputs
Outputs of similar age from GE-Portuguese Journal of Gastroenterology
#4
of 9 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 198 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,826 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.