Title |
Recomendaciones para el uso de everolimus en trasplante renal de novo: falsas creencias, mitos y realidades
|
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Published in |
Nefrología, May 2017
|
DOI | 10.1016/j.nefro.2016.11.007 |
Pubmed ID | |
Authors |
Julio Pascual, Fritz Diekmann, Constantino Fernández-Rivera, Gonzalo Gómez-Marqués, Alex Gutiérrez-Dalmau, María José Pérez-Sáez, Asunción Sancho-Calabuig, Federico Oppenheimer |
Abstract |
The immunosuppressive combination most commonly used in de novo kidney transplantation comprises a calcineurin inhibitor (CI), tacrolimus, a mycophenolic acid derivative and steroids. The evidence which underlies this practice is based in the Symphony trial with controlled follow-up of one year, in which no comparator group included the combination CI-mTOR inhibitor. Different high-quality clinical trials support the use of everolimus as a standard immunosuppressive drug associated with reduced exposure of a CI in kidney transplantation. This combination could improve health related outcomes in kidney transplantation recipients. The present recommendations constitute an attempt to summarise the scientific evidence supporting this practice, discuss false beliefs, myths and facts, and offer specific guidelines for safe use, avoiding complications. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 3 | 8% |
Student > Master | 3 | 8% |
Student > Bachelor | 3 | 8% |
Other | 2 | 5% |
Researcher | 2 | 5% |
Other | 3 | 8% |
Unknown | 22 | 58% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 26% |
Nursing and Health Professions | 3 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Environmental Science | 1 | 3% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 0 | 0% |
Unknown | 22 | 58% |