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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador
|
|---|---|
| Published in |
Revista Argentina de Microbiología, November 2017
|
| DOI | 10.1016/j.ram.2017.06.004 |
| Pubmed ID | |
| Authors |
Cesar H. Bedoya-Pilozo, Lex G. Medina Magües, Maylen Espinosa-García, Martha Sánchez, Johanna V. Parrales Valdiviezo, Denisse Molina, María A. Ibarra, María Quimis-Ponce, Karool España, Karla E. Párraga Macias, Nancy V. Cajas Flores, Solon A. Orlando, Jorge A. Robalino Penaherrera, Peter Chedraui, Saul Escobar, Rita D. Loja Chango, Cecibel Ramirez-Morán, Jasson Espinoza-Caicedo, Sunny Sánchez-Giler, Celia M. Limia, Yoan Alemán, Yudira Soto, Vivian Kouri, Andrés C.A. Culasso, Inés Badano |
| Abstract |
The aim of the present study was to gather information regarding the molecular epidemiology of Human papillomavirus (HPV) and related risk factors in a group of women with low- and high-grade cervical lesions and cancer from the coastal region of Ecuador. In addition, we studied the evolution of HPV variants from the most prevalent types and provided a temporal framework for their emergence, which may help to trace the source of dissemination within the region. We analyzed 166 samples, including 57 CIN1, 95 CIN2/3 and 14 cancer cases. HPV detection and typing was done by PCR-sequencing (MY09/MY11). HPV variants and estimation of the time to most recent common ancestor (tMRCA) was assessed through phylogeny and coalescence analysis. HPV DNA was found in 54.4% of CIN1, 74.7% of CIN2/3 and 78.6% of cancer samples. HPV16 (38.9%) and HPV58 (19.5%) were the most prevalent types. Risk factors for the development of cervical lesions/cancer were the following: three or more pregnancies (OR=4.3), HPV infection (OR=3.7 for high-risk types; OR=3.5 for HPV16), among others. With regard to HPV evolution, HPV16 isolates belonged to lineages A (69%) and D (31%) whereas HPV58 isolates belonged only to lineage A. The period of emergence of HPV16 was in association with human populations (tMRCA=91052 years for HPV16A and 27000 years for HPV16D), whereas HPV58A preceded Homo sapiens evolution (322257 years). This study provides novel data on HPV epidemiology and evolution in Ecuador, which will be fundamental in the vaccine era. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ecuador | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 123 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 13% |
| Student > Bachelor | 16 | 13% |
| Researcher | 11 | 9% |
| Student > Doctoral Student | 11 | 9% |
| Student > Postgraduate | 7 | 6% |
| Other | 15 | 12% |
| Unknown | 47 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 24% |
| Biochemistry, Genetics and Molecular Biology | 22 | 18% |
| Agricultural and Biological Sciences | 9 | 7% |
| Nursing and Health Professions | 7 | 6% |
| Economics, Econometrics and Finance | 3 | 2% |
| Other | 8 | 7% |
| Unknown | 45 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2019.
All research outputs
#16,725,651
of 25,382,440 outputs
Outputs from Revista Argentina de Microbiología
#87
of 327 outputs
Outputs of similar age
#266,001
of 445,134 outputs
Outputs of similar age from Revista Argentina de Microbiología
#6
of 21 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 327 research outputs from this source. They receive a mean Attention Score of 1.7. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,134 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.