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Influência dos polimorfismos genéticos (IL10/CXCL8/CXCR2/ NFκB) na susceptibilidade das doenças reumatológicas autoimunes

Overview of attention for article published in Advances in Rheumatology, August 2014
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Title
Influência dos polimorfismos genéticos (IL10/CXCL8/CXCR2/ NFκB) na susceptibilidade das doenças reumatológicas autoimunes
Published in
Advances in Rheumatology, August 2014
DOI 10.1016/j.rbr.2013.10.006
Pubmed ID
Authors

Patricia Hartstein Salim, Ricardo Machado Xavier

Abstract

The autoimmune rheumatologic disorders mostly have a common genetic path to the autoimmunity. Several genes have been associated with rheumatologic disorders; therefore, we are analyzing just the ones in those containing several evidences of the existence of association with the risk or protection from autoimmune disorder. The nuclear factor kappa beta (NF-kappa B), which regulates the autoimmune and anti-inflammatory responses, is associated with systemic sclerosis (SS), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), just as the CXCR2 e CXCL8 genes. On the other hand, the interleukin-10 (IL-10), which is an anti-inflammatory cytokine, is associated with almost all rheumatologic disorders. In this article, we are reviewing the potential roles of these genes in the immune system and in several rheumatologic disorders. In relation to IL-10, several studies have been carried out, but most of them are controversial - some detected the absence of association, and others found association in different genetic polymorphisms. Conversely, in relation to NF-kappa B, it was studied just in RA and SLE, and no relevant significant analyses were observed. The genetic polymorphisms of the CXCR2 gene were associated with SS, but not with RA e SLE. On the other side, the genetic polymorphisms of the CXCL8 gene are not associated with SS, but with RA.

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The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 14%
Student > Bachelor 1 14%
Other 1 14%
Student > Master 1 14%
Unknown 3 43%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 14%
Immunology and Microbiology 1 14%
Chemistry 1 14%
Unknown 4 57%