Title |
Conceptos generales de epigenética: proyecciones en pediatría
|
---|---|
Published in |
Revista chilena de pediatría, February 2016
|
DOI | 10.1016/j.rchipe.2015.12.002 |
Pubmed ID | |
Authors |
Bernardo J. Krause, José A. Castro-Rodríguez, Ricardo Uauy, Paola Casanello |
Abstract |
Current evidence supports the notion that alterations in intrauterine growth and during the first years of life have a substantial effect on the risk for the development of chronic disease, which in some cases is even higher than those due to genetic factors. The persistence and reproducibility of the phenotypes associated with altered early development suggest the participation of mechanisms that would record environmental cues, generating a cellular reprogramming (i.e. epigenetic mechanisms). This review is an introduction to a series of five articles focused on the participation of epigenetic mechanisms in the development of highly prevalent chronic diseases (i.e. cardiovascular, metabolic, asthma/allergies and cancer) and their origins in the foetal and neonatal period. This series of articles aims to show the state of the art in this research area and present the upcoming clues and challenges, in which paediatricians have a prominent role, developing strategies for the prevention, early detection and follow-up. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 2 | 50% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 180 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 38 | 21% |
Student > Master | 24 | 13% |
Other | 13 | 7% |
Student > Postgraduate | 13 | 7% |
Researcher | 12 | 7% |
Other | 33 | 18% |
Unknown | 47 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 43 | 24% |
Biochemistry, Genetics and Molecular Biology | 24 | 13% |
Nursing and Health Professions | 18 | 10% |
Agricultural and Biological Sciences | 13 | 7% |
Immunology and Microbiology | 6 | 3% |
Other | 32 | 18% |
Unknown | 44 | 24% |