Title |
Segurança da vacina papillomavirus humano 6, 11, 16 e 18 (recombinante): revisão sistemática e metanálise
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Published in |
Revista Paulista de Pediatria, August 2015
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DOI | 10.1016/j.rpped.2015.02.006 |
Pubmed ID | |
Authors |
Pedro Luiz Spinelli Coelho, Gustavo Lacerda da Silva Calestini, Fernando Salgueiro Alvo, Jefferson Michel de Moura Freitas, Paula Marcela Vilela Castro, Tulio Konstantyner |
Abstract |
To identify and quantify the adverse effects associated with the recombinant human papillomavirus (types 6, 11, 16 and 18) vaccine in adolescents. Systematic review of randomized clinical trials from PubMed, SciELO and Lilacs databases. Articles investigating the safety of the vaccine in subjects under 18 years and comparing the recombinant human papillomavirus types 6, 11, 16 and 18 vaccine with a control group were included. Meta-analyses were performed for the outcomes of pain, erythema, swelling and fever, using clinical trials with maximum Jadad score. Fourteen studies were included. The most commons adverse effects related to the human papillomavirus vaccine were effects with no severity (pain, erythema, edema, and fever). Five studies were used for the meta-analyses: Pain-Risk Difference (RD)=11% (p<0.001); edema-RD=8% (p<0.001); erythema-RD=5% (p<0.001); fever-RD=2% (p<0.003). The recombinant human papillomavirus types 6, 11, 16 and 18 vaccine was safe and well tolerated. The main adverse effects related to vaccination were pain, erythema, edema and fever. The low frequency of severe adverse effects encourages the administration of the vaccine in the population at risk. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 29% |
Ireland | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 57% |
Scientists | 2 | 29% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 36% |
Student > Master | 5 | 18% |
Student > Doctoral Student | 3 | 11% |
Student > Ph. D. Student | 1 | 4% |
Researcher | 1 | 4% |
Other | 1 | 4% |
Unknown | 7 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 18% |
Nursing and Health Professions | 3 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Agricultural and Biological Sciences | 2 | 7% |
Immunology and Microbiology | 2 | 7% |
Other | 4 | 14% |
Unknown | 10 | 36% |