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Elderly people with human T-cell leukemia virus type 1-associated myelopathy present an early impairment in cognitive skills

Overview of attention for article published in Arquivos de Neuro-Psiquiatria, April 2023
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Title
Elderly people with human T-cell leukemia virus type 1-associated myelopathy present an early impairment in cognitive skills
Published in
Arquivos de Neuro-Psiquiatria, April 2023
DOI 10.1055/s-0043-1763486
Pubmed ID
Authors

Beatriz Rezende Matos de Sousa, Ludimila Labanca, Maria Luiza Diniz, Nathália de Castro Botini Rausse, Denise Utsch Gonçalves

Abstract

 Cerebral changes occur in individuals with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) and seem to predominate in subcortical areas. Little is known about the cognitive decline in the elderly living with HTLV-1.  To evaluate the cognitive aging of individuals infected with HTLV-1 aged ≥ 50 years.  This is a cross-sectional study of former blood donors infected with HTLV-1 who have been followed in the cohort of the Interdisciplinary Research Group on HTLV-1 since 1997. The groups of study consisted of 79 HTLV-1 infected individuals aged ≥ 50 years, with 41 of them presenting symptomatic HAM and 38 being asymptomatic carriers, and 59 seronegative individuals (controls) aged ≥ 60 years. All were submitted to the P300 electrophysiological test and neuropsychological tests.  Individuals with HAM presented delayed P300 latency in relation to the other groups, and this latency delay increased progressively with aging. The performance of this group in the neuropsychological tests was also the worst. The HTLV-1- asymptomatic group performance was similar to that of the control group.  Individuals with HAM presented cognitive decline that progressed with aging and, although HTLV-1-asymptomatic carriers appear to present cognitive aging similar to that of healthy elderly people, concern about a subclinical cognitive impairment is warranted in this population.

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Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 20%
Unknown 4 80%
Readers by discipline Count As %
Social Sciences 1 20%
Neuroscience 1 20%
Unknown 3 60%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2023.
All research outputs
#17,539,395
of 25,713,737 outputs
Outputs from Arquivos de Neuro-Psiquiatria
#767
of 1,376 outputs
Outputs of similar age
#246,879
of 419,415 outputs
Outputs of similar age from Arquivos de Neuro-Psiquiatria
#11
of 16 outputs
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