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Cost effectiveness of the cancer prevention program for carriers of the BRCA1/2 mutation

Overview of attention for article published in Revista de Saúde Pública, November 2018
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Title
Cost effectiveness of the cancer prevention program for carriers of the BRCA1/2 mutation
Published in
Revista de Saúde Pública, November 2018
DOI 10.11606/s1518-8787.2018052000643
Pubmed ID
Authors

Marcelo Cristiano de Azevedo Ramos, Maria Aparecida Azevedo Koike Folgueira, Simone Maistro, Alessandro Gonçalves Campolina, Patricia Coelho de Soárez, Geertruida Hendrika de Bock, Hillegonda Maria Dutilh Novaes, Maria Del Pilar Estevez Diz

Abstract

To analyze the cost effectiveness of the diagnostic program for the germline mutation in BRCA1/2 genes and of preventative strategies for the relatives of patients diagnosed with ovarian cancer associated with this mutation. The study analyzed the cost effectiveness by developing an analysis of the Markov decision process from the perspective of the National Health System. The strategies compared reflect upon the adoption of genetic testing and preventative strategies for relatives or the usual care currently proposed. The incremental cost-effectiveness ratio was expressed in terms of cost per case avoided. The sensitivity analysis was performed in a univariate and deterministic manner. The study showed increments for effectiveness and for costs when performing genetic testing and adopting prophylactic measures for family members. The incremental cost-effectiveness ratio was estimated at R$908.58 per case of cancer avoided, a figure considered lower than the study's cost-effectiveness threshold (R$7,543.50). The program analyzed should be considered a cost-effective strategy for the national situation. Studies in various other countries have reached similar conclusions. One possible ramification of this research might the need to perform a budgetary-impact analysis of making the program one of the country's health policies.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 65 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 14 22%
Student > Master 6 9%
Other 5 8%
Researcher 5 8%
Student > Bachelor 4 6%
Other 11 17%
Unknown 20 31%
Readers by discipline Count As %
Unspecified 14 22%
Medicine and Dentistry 11 17%
Biochemistry, Genetics and Molecular Biology 4 6%
Economics, Econometrics and Finance 3 5%
Nursing and Health Professions 2 3%
Other 10 15%
Unknown 21 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2018.
All research outputs
#20,663,600
of 25,385,509 outputs
Outputs from Revista de Saúde Pública
#896
of 1,138 outputs
Outputs of similar age
#341,818
of 446,120 outputs
Outputs of similar age from Revista de Saúde Pública
#5
of 9 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,138 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,120 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.