Title |
Toxins from the Caribbean sea anemone Bunodeopsis globulifera increase cisplatin-induced cytotoxicity of lung adenocarcinoma cells
|
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Published in |
Journal of Venomous Animals and Toxins including Tropical Diseases, May 2013
|
DOI | 10.1186/1678-9199-19-12 |
Pubmed ID | |
Authors |
Heidi I Monroy-Estrada, Yolanda I Chirino, Irma E Soria-Mercado, Judith Sánchez-Rodríguez |
Abstract |
Lung cancer causes 1.4 million deaths worldwide while non-small-cell lung cancer (NSCLC) represents 80-85% of the cases. Cisplatin is a standard chemotherapy against this type of cancer; however, tumor cell resistance to this drug limits its efficacy. Sea anemones produce compounds with pharmacological activities that may be useful for augmenting cisplatin efficacy. This study aimed to evaluate the pharmacological activities of crude venom (CV) from the sea anemone Bunodeopsis globulifera and four derived fractions (F1, F2, F3 and F4) to test their increase efficiency cisplatin cytotoxicity in human lung adenocarcinoma cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 2 | 8% |
Unknown | 23 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 24% |
Student > Master | 5 | 20% |
Student > Doctoral Student | 4 | 16% |
Researcher | 3 | 12% |
Student > Postgraduate | 2 | 8% |
Other | 3 | 12% |
Unknown | 2 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 40% |
Chemistry | 4 | 16% |
Biochemistry, Genetics and Molecular Biology | 3 | 12% |
Medicine and Dentistry | 2 | 8% |
Chemical Engineering | 1 | 4% |
Other | 2 | 8% |
Unknown | 3 | 12% |