Title |
Bufotenine is able to block rabies virus infection in BHK-21 cells
|
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Published in |
Journal of Venomous Animals and Toxins including Tropical Diseases, October 2014
|
DOI | 10.1186/1678-9199-20-45 |
Pubmed ID | |
Authors |
Hugo Vigerelli, Juliana Mozer Sciani, Carlos Jared, Marta Maria Antoniazzi, Graciane Maria Medeiros Caporale, Andréa de Cássia Rodrigues da Silva, Daniel C Pimenta |
Abstract |
Rabies is a fatal zoonotic neglected disease that occurs in more than 150 countries, and kills more than 55.000 people every year. It is caused by an enveloped single stranded RNA virus that affects the central nervous system, through an infection initiated by the muscular nicotinic acetylcholine receptor, according to many authors. Alkaloids, such as acetylcholine, are widespread molecules in nature. They are present in numerous biological fluids, including the skin secretion of many amphibians, in which they act (together with proteins, peptides and steroids) as protection agents against predators and/or microorganisms. Among those amphibians that are rich in alkaloids, there is the genus Rhinella. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 3% |
Nigeria | 1 | 1% |
Unknown | 74 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 14% |
Student > Master | 11 | 14% |
Student > Ph. D. Student | 9 | 12% |
Student > Bachelor | 8 | 10% |
Student > Postgraduate | 8 | 10% |
Other | 12 | 16% |
Unknown | 18 | 23% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 16 | 21% |
Agricultural and Biological Sciences | 16 | 21% |
Chemistry | 5 | 6% |
Medicine and Dentistry | 4 | 5% |
Nursing and Health Professions | 2 | 3% |
Other | 11 | 14% |
Unknown | 23 | 30% |