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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations
|
|---|---|
| Published in |
Biological Research, July 2015
|
| DOI | 10.1186/s40659-015-0033-8 |
| Pubmed ID | |
| Authors |
Hiroshi Takahashi, Kazuhiko Ikeda, Kazuei Ogawa, Syunnichi Saito, Alain M Ngoma, Yumiko Mashimo, Koki Ueda, Miki Furukawa, Akiko Shichishima-Nakamura, Hiroshi Ohkawara, Kenneth E Nollet, Hitoshi Ohto, Yasuchika Takeishi |
| Abstract |
CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable. We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher proportions of total Treg cells 1 month post allo-HSCT, and naïve Treg cells 1 year post allo-HSCT, appeared in patients achieving complete chimera without developing significant chronic GVHD, including our thymectomized patient, compared with patients who developed chronic GVHD. Treg cells that modulate human allogeneic immunity may arise peripherally as well as in the thymus of allo-HSCT recipients. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 50% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 6% |
| Unknown | 17 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 22% |
| Student > Master | 3 | 17% |
| Professor | 2 | 11% |
| Student > Ph. D. Student | 2 | 11% |
| Other | 1 | 6% |
| Other | 3 | 17% |
| Unknown | 3 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 56% |
| Computer Science | 1 | 6% |
| Immunology and Microbiology | 1 | 6% |
| Engineering | 1 | 6% |
| Unknown | 5 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2017.
All research outputs
#14,915,476
of 25,374,917 outputs
Outputs from Biological Research
#192
of 642 outputs
Outputs of similar age
#129,370
of 274,657 outputs
Outputs of similar age from Biological Research
#2
of 20 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 642 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,657 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.