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Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities

Overview of attention for article published in Anais da Academia Brasileira de Ciências, June 2017
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Title
Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities
Published in
Anais da Academia Brasileira de Ciências, June 2017
DOI 10.1590/0001-3765201720160801
Pubmed ID
Authors

Zenaide S Monte, Amanda M Silva, Gláucia M S Lima, Teresinha G DA Silva, Karla M R Marques, Maria D Rodrigues, Emerson P S Falcão, Sebastião J Melo

Abstract

A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteric; and against the yeast, candida albicans. Further, the Minimum Inhibitory Concentrations (MIC) against the bacteria and yeast were determined. All compounds 3a-d, 3f, 3g, 3i and 3j were also investigated for their low cytotoxic effects on tested cell lines. Compounds 3d and 3f were the most effective derivatives against HL-60 and HEp-2 cells, respectively, with IC50 value (2µg/mL), and low normal cells toxicity.

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Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 44%
Professor 1 11%
Student > Doctoral Student 1 11%
Student > Master 1 11%
Unknown 2 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 22%
Engineering 2 22%
Pharmacology, Toxicology and Pharmaceutical Science 1 11%
Computer Science 1 11%
Agricultural and Biological Sciences 1 11%
Other 2 22%