Title |
Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities
|
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Published in |
Anais da Academia Brasileira de Ciências, June 2017
|
DOI | 10.1590/0001-3765201720160801 |
Pubmed ID | |
Authors |
Zenaide S Monte, Amanda M Silva, Gláucia M S Lima, Teresinha G DA Silva, Karla M R Marques, Maria D Rodrigues, Emerson P S Falcão, Sebastião J Melo |
Abstract |
A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteric; and against the yeast, candida albicans. Further, the Minimum Inhibitory Concentrations (MIC) against the bacteria and yeast were determined. All compounds 3a-d, 3f, 3g, 3i and 3j were also investigated for their low cytotoxic effects on tested cell lines. Compounds 3d and 3f were the most effective derivatives against HL-60 and HEp-2 cells, respectively, with IC50 value (2µg/mL), and low normal cells toxicity. |
X Demographics
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Australia | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
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Student > Bachelor | 4 | 44% |
Professor | 1 | 11% |
Student > Doctoral Student | 1 | 11% |
Student > Master | 1 | 11% |
Unknown | 2 | 22% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 1 | 11% |
Computer Science | 1 | 11% |
Agricultural and Biological Sciences | 1 | 11% |
Other | 2 | 22% |