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Accuracy of immunoglobulin M and immunoglobulin A of saliva in early diagnosis of dengue: Systematic Review and Meta-analysis

Overview of attention for article published in Anais da Academia Brasileira de Ciências, September 2018
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Title
Accuracy of immunoglobulin M and immunoglobulin A of saliva in early diagnosis of dengue: Systematic Review and Meta-analysis
Published in
Anais da Academia Brasileira de Ciências, September 2018
DOI 10.1590/0001-3765201820170989
Pubmed ID
Authors

Tamy Colonetti, Belise V E Rocha, Antônio J Grande, Maria C M Alexandre, Eduardo R Dondossola, Kristian Madeira, Maria I Rosa

Abstract

The objective of the study was to conduct a systematic review to synthesize the current evidence on the accuracy of IgM and IgA to early diagnosis the dengue virus. The review protocol was registered at PROSPERO (CRD 42015024808). We searched for studies in the following electronic database from 1990 to January 2018. The search identified 3507 studies. Five studies were included for quantitative analysis. Three studies included evaluations of salivary IgM provided a sensitivity of 86% and specificity of 93%. Two studies included evaluating of IgA salivary showed a combined sensitivity of 69% and a combined specificity of 98%. Despite the results found and the low methodological quality of the studies included in the meta-analysis it is still soon to claim that IgA is better than IgM to diagnosis Dengue.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 18%
Researcher 4 12%
Student > Doctoral Student 2 6%
Other 2 6%
Student > Master 2 6%
Other 2 6%
Unknown 16 47%
Readers by discipline Count As %
Medicine and Dentistry 7 21%
Biochemistry, Genetics and Molecular Biology 4 12%
Agricultural and Biological Sciences 3 9%
Nursing and Health Professions 1 3%
Immunology and Microbiology 1 3%
Other 3 9%
Unknown 15 44%