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Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample

Overview of attention for article published in Arquivos de Neuro-Psiquiatria, August 2014
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Title
Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
Published in
Arquivos de Neuro-Psiquiatria, August 2014
DOI 10.1590/0004-282x20140100
Pubmed ID
Authors

Quirino Cordeiro, Homero Vallada

Abstract

Schizophrenia is a severe psychotic disorder with recurrent relapse and functional impairment. It results from a poorly understood gene-environment interaction. The Taq1A polymorphism (located in the gene cluster NTAD) is a likely candidate for schizophrenia. Its rs1800497 polymorphism was shown to be associated with DRD2 gene expression. Therefore the present work aims to investigate a possible association between schizophrenia and such polymorphism. The compared distribution of the alleles and genotypes of the studied polymorphism was investigated in a Brazilian sample of 235 patients and 834 controls. Genotypic frequencies were in Hardy-Weinberg equilibrium. There was a trend of allelic association between the Taq1A polymorphism (rs1800497) with schizophrenia in the studied sample. However no statistically differences were found between cases and controls when analyzed by gender or schizophrenia subtypes.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 17%
Lecturer 3 10%
Student > Bachelor 3 10%
Researcher 3 10%
Student > Ph. D. Student 3 10%
Other 6 21%
Unknown 6 21%
Readers by discipline Count As %
Medicine and Dentistry 6 21%
Biochemistry, Genetics and Molecular Biology 4 14%
Agricultural and Biological Sciences 4 14%
Neuroscience 2 7%
Psychology 2 7%
Other 1 3%
Unknown 10 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2015.
All research outputs
#22,760,732
of 25,374,917 outputs
Outputs from Arquivos de Neuro-Psiquiatria
#1,140
of 1,368 outputs
Outputs of similar age
#206,173
of 240,212 outputs
Outputs of similar age from Arquivos de Neuro-Psiquiatria
#17
of 20 outputs
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