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Attention Score in Context
| Title |
Genetic predisposition to higher production of interleukin-6 through -174 G > C polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia
|
|---|---|
| Published in |
Arquivos de Neuro-Psiquiatria, November 2015
|
| DOI | 10.1590/0004-282x20150137 |
| Pubmed ID | |
| Authors |
Vanessa G. Fraga, Henrique C. Guimarães, Antônio L. Teixeira, Maira T. Barbosa, Elvis C. C. Mateo, Maria G. Carvalho, Paulo Caramelli, Karina B. Gomes |
| Abstract |
Interleukin 6 (IL-6) is a pro-inflammatory cytokine upregulated in neurodegenerative contexts. The polymorphism IL-6 -174 G > C influences release levels of this cytokine. We aimed to evaluate the influence of IL-6 -174 G > C on global cognitive score of a group with cognitive impairment no dementia in one year of follow-up.Methods The subjects were categorized in two groups: short-term decline in global cognitive score and those with short-term stability or improvement. IL-6 174 G > C information were compared among these groups.Results We observed that individuals with cognitive impairment no dementia with GGlowergenotype were more frequent among global cognitive score non-decliners while carriers of at least one Chigherallele were more frequent in the group with global cognitive score decliners (p = 0.012; RR = 3.095 IC95%= 1.087-8.812).Conclusion These results suggest that the higher expression of IL-6 gene may be an independent risk factor for cognitive decline among individuals with cognitive impairment no dementia. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 8 | 20% |
| Student > Ph. D. Student | 6 | 15% |
| Other | 5 | 12% |
| Student > Postgraduate | 4 | 10% |
| Student > Bachelor | 3 | 7% |
| Other | 6 | 15% |
| Unknown | 9 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 24% |
| Nursing and Health Professions | 5 | 12% |
| Psychology | 5 | 12% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Neuroscience | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 13 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2015.
All research outputs
#3,123,840
of 22,830,751 outputs
Outputs from Arquivos de Neuro-Psiquiatria
#97
of 1,252 outputs
Outputs of similar age
#46,309
of 284,445 outputs
Outputs of similar age from Arquivos de Neuro-Psiquiatria
#1
of 18 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,252 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,445 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.