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Current concepts in the treatment of hereditary ataxias

Overview of attention for article published in Arquivos de Neuro-Psiquiatria, March 2016
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Title
Current concepts in the treatment of hereditary ataxias
Published in
Arquivos de Neuro-Psiquiatria, March 2016
DOI 10.1590/0004-282x20160038
Pubmed ID
Authors

Pedro Braga, José Luiz Pedroso, Sheng-Han Kuo, C. França Marcondes, Hélio Afonso Ghizoni Teive, Orlando Graziani Povoas Barsottini

Abstract

Hereditary ataxias (HA) represents an extensive group of clinically and genetically heterogeneous neurodegenerative diseases, characterized by progressive ataxia combined with extra-cerebellar and multi-systemic involvements, including peripheral neuropathy, pyramidal signs, movement disorders, seizures, and cognitive dysfunction. There is no effective treatment for HA, and management remains supportive and symptomatic. In this review, we will focus on the symptomatic treatment of the main autosomal recessive ataxias, autosomal dominant ataxias, X-linked cerebellar ataxias and mitochondrial ataxias. We describe management for different clinical symptoms, mechanism-based approaches, rehabilitation therapy, disease modifying therapy, future clinical trials and perspectives, genetic counseling and preimplantation genetic diagnosis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 75 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 17%
Other 6 8%
Student > Master 6 8%
Student > Ph. D. Student 6 8%
Student > Postgraduate 5 7%
Other 13 17%
Unknown 26 35%
Readers by discipline Count As %
Medicine and Dentistry 14 19%
Biochemistry, Genetics and Molecular Biology 9 12%
Nursing and Health Professions 9 12%
Neuroscience 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 7 9%
Unknown 27 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2017.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Arquivos de Neuro-Psiquiatria
#997
of 1,369 outputs
Outputs of similar age
#231,192
of 312,604 outputs
Outputs of similar age from Arquivos de Neuro-Psiquiatria
#17
of 22 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,369 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.