Title |
Usefulness of diffusion tensor imaging in amyotrophic lateral sclerosis: potential biomarker and association with the cognitive profile
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Published in |
Arquivos de Neuro-Psiquiatria, May 2017
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DOI | 10.1590/0004-282x20170032 |
Pubmed ID | |
Authors |
Marcelo Chaves, Mariela Bettini, Maria Cecilia Fernandez, Maria Jose Garcia Basalo, Juan Ignacio Rojas, Cristina Besada, Edgardo Cristiano, Angel Golimstok, Marcelo Rugiero |
Abstract |
This was a case-control study conducted from December 1, 2012 to December 1, 2014. Clinical and demographic data were recorded. A neuropsychological test battery adapted to ALS patients was used. An MRI with DTI was performed in all patients and fractional anisotropy (FA) was analyzed in the white matter using the tract based spatial statistics program. Twenty-four patients with ALS (15 females, mean age 66.9 + -2.3) and 13 healthy controls (four females, average age 66.9 + - 2) were included. The DTI showed white matter damage in ALS patients vs. healthy controls (p < 0.001). In our preliminary study the alterations of white matter in DTI were significantly associated with cognitive impairment in patients with ALS. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 20% |
Student > Bachelor | 5 | 17% |
Researcher | 4 | 13% |
Other | 2 | 7% |
Student > Doctoral Student | 1 | 3% |
Other | 4 | 13% |
Unknown | 8 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 33% |
Psychology | 4 | 13% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Neuroscience | 2 | 7% |
Chemical Engineering | 1 | 3% |
Other | 0 | 0% |
Unknown | 11 | 37% |