Title |
Late onset multiple sclerosis: concerns in aging patients
|
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Published in |
Arquivos de Neuro-Psiquiatria, July 2017
|
DOI | 10.1590/0004-282x20170070 |
Pubmed ID | |
Authors |
Claudia Beatriz de Campos Lotti, Acary Souza Bulle Oliveira, Denis Bernardi Bichuetti, Isac de Castro, Enedina Maria Lobato Oliveira |
Abstract |
Late onset multiple sclerosis (LOMS) is when the first symptom starts after 50 years of age, representing 4.5% of multiple sclerosis (MS) patients. This study describes the clinical characteristics of patients with LOMS followed at a specialized MS center in São Paulo. Data was obtained from medical records of 742 patients with MS. The LOMS frequency was 4.18%, median age at onset was 54 years and the predominant disease course was primary progressive (64.3%). The patients reached the disability landmarks of EDSS grades 3.0, 6.0 and 7.0 in the following proportion and time: EDSS 3.0: 77.42% of patients in 3.7 years; EDSS 6.0: 58.06% in 5.1 years and EDSS 7.0: 32.26% in 5.7 years. The comparative analysis with a matched control group of patients with early onset MS showed that late onset, associated with a progressive course, were predictors of reaching EDSS 3.0 and 6.0 in a shorter time. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 3 | 38% |
Unknown | 5 | 63% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 88% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 19% |
Student > Bachelor | 7 | 17% |
Student > Master | 6 | 14% |
Student > Doctoral Student | 5 | 12% |
Student > Ph. D. Student | 5 | 12% |
Other | 3 | 7% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 43% |
Neuroscience | 7 | 17% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Nursing and Health Professions | 2 | 5% |
Psychology | 1 | 2% |
Other | 1 | 2% |
Unknown | 10 | 24% |