Title |
Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke
|
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Published in |
Arquivos de Neuro-Psiquiatria, January 2018
|
DOI | 10.1590/0004-282x20170180 |
Pubmed ID | |
Authors |
Jean M C Monteiro, Daniel L San-Martin, Beatriz C G Silva, Pedro A P de Jesus, Jamary Oliveira Filho |
Abstract |
To describe anticoagulation characteristics in patients with cardiac complications from Chagas disease and compare participants with and without cardioembolic ischemic stroke (CIS). A retrospective cohort of patients with Chagas disease, using anticoagulation, conducted from January 2011 to December 2014. Forty-two patients with Chagas disease who were using anticoagulation were studied (age 62.9±12.4 years), 59.5% female and 47.6% with previous CIS, 78.6% with non-valvular atrial fibrillation and 69.7% with dilated cardiomyopathy. Warfarin was used in 78.6% of patients and dabigatran (at different times) in 38%. In the warfarin group, those with CIS had more medical appointments per person-years of follow-up (11.7 vs 7.9), a higher proportion of international normalized ratios within the therapeutic range (57% vs 42% medical appointments, p = 0.025) and an eight times higher frequency of minor bleeding (0.64 vs 0.07 medical appointments). Patients with Chagas disease and previous CIS had better control of INR with a higher frequency of minor bleeding. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 14% |
Student > Ph. D. Student | 5 | 14% |
Student > Master | 4 | 11% |
Student > Postgraduate | 4 | 11% |
Other | 2 | 6% |
Other | 3 | 8% |
Unknown | 13 | 36% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Mathematics | 1 | 3% |
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Nursing and Health Professions | 1 | 3% |
Other | 2 | 6% |
Unknown | 15 | 42% |