Title |
Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant Enterococcus faecalis
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Published in |
Revista da Sociedade Brasileira de Medicina Tropical, October 2015
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DOI | 10.1590/0037-8682-0017-2015 |
Pubmed ID | |
Authors |
Tiane Martin de Moura, Fabrício Souza Campos, Juliana Caierão, Ana Claudia Franco, Paulo Michel Roehe, Pedro Alves d'Azevedo, Jeverson Frazzon, Ana Paula Guedes Frazzon |
Abstract |
Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome. Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin. A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro . Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 20% |
Researcher | 3 | 12% |
Student > Doctoral Student | 3 | 12% |
Professor | 2 | 8% |
Student > Ph. D. Student | 2 | 8% |
Other | 5 | 20% |
Unknown | 5 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 16% |
Agricultural and Biological Sciences | 4 | 16% |
Biochemistry, Genetics and Molecular Biology | 3 | 12% |
Nursing and Health Professions | 1 | 4% |
Unspecified | 1 | 4% |
Other | 5 | 20% |
Unknown | 7 | 28% |