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Mendeley readers
| Title |
Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease
|
|---|---|
| Published in |
Revista da Sociedade Brasileira de Medicina Tropical, September 2017
|
| DOI | 10.1590/0037-8682-0025-2017 |
| Pubmed ID | |
| Authors |
Matheus Barbosa de Miranda, Adriene Siqueira de Melo, Mariana Silva Almeida, Silvia Martins Marinho, Wilson Oliveira, Yara de Miranda Gomes |
| Abstract |
Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets. The ex vivo phenotypic expression of chemokine receptors CCR1, CCR3, CCR4, CCR5, CXCR2, CXCR3, CXCR4, and CXCR5 on the CD4+ and CD8+ T-cells of patients with chronic Chagas cardiomyopathy of varying severity was evaluated using flow cytometry. Differential expression of CD4+CCR3+ and CD8+CCR4+ T-cells was observed in patients with mild cardiac involvement compared, respectively, with patients with severe cardiac and asymptomatic forms of Chagas disease. These receptors are possibly involved in the pathogenesis of chronic Chagas cardiomyopathy. |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 19% |
| Researcher | 3 | 14% |
| Student > Master | 2 | 10% |
| Student > Ph. D. Student | 2 | 10% |
| Student > Doctoral Student | 1 | 5% |
| Other | 5 | 24% |
| Unknown | 4 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 4 | 19% |
| Agricultural and Biological Sciences | 4 | 19% |
| Medicine and Dentistry | 2 | 10% |
| Engineering | 2 | 10% |
| Business, Management and Accounting | 1 | 5% |
| Other | 4 | 19% |
| Unknown | 4 | 19% |